Issue 9, 1990
From the journal:

Analyst

Continuous-flow chemiluminescence determination of isoniazid by oxidation with N-bromosuccinimide

Stergios A. Halvatzis,   Meropi M. Timotheou-Potamia  and  Antony C. Calokerinos  

Abstract

A rapid and precise continuous-flow method is described for the determination of isoniazid (0.050–20.0 µg ml–1) based on the chemiluminescence produced during its reaction with N-bromosuccinimide in alkaline medium. The emission intensity is greatly enhanced by the presence of ammonia. The procedure is automated and samples can be analysed at a rate of 112 solutions per hour with a relative error of about 2%. When applied to tablets, the method is relatively free from interferences from common excipients and co-existing compounds. The results obtained for the assay of commercial preparations compared well with those obtained by an official chemical method and demonstrated good accuracy and precision.

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Article information

DOI
https://doi.org/10.1039/AN9901501229
Article type
Paper

Analyst, 1990,115, 1229-1234

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Continuous-flow chemiluminescence determination of isoniazid by oxidation with N-bromosuccinimide

S. A. Halvatzis, M. M. Timotheou-Potamia and A. C. Calokerinos, Analyst, 1990, 115, 1229 DOI: 10.1039/AN9901501229

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