Issue 53, 2019
From the journal:

RSC Advances

DNA/lysozyme binding propensity and nuclease properties of benzimidazole/2,2′-bipyridine based binuclear ternary transition metal complexes†

Ahmed M. Mansour ORCID logo *a  and  Mona S. Ragab ORCID logo a  

* Corresponding authors

a Department of Chemistry, Faculty of Science, Cairo University, Gamma Street, Giza, Cairo 12613, Egypt
E-mail: mansour@sci.cu.edu.eg

Abstract

In the present contribution, new binuclear ternary complexes; [M2(bpy)4L](ClO4)4 (M = Co(II) (1) and Ni(II) (2); bpy = 2,2′-bipyridine; L = 1,1′-(hexane-1,6-diyl)bis[2-(pyridin-2-yl)1H-benzimidazole] and [Cu2(bpy)2(OH2)2L](BF4)4 (3) were synthesized, characterized and screened for their antimicrobial activity and cytotoxicity against human liver carcinoma cells (HepG-2) as well as non-malignant human embryonic kidney cells (HEK-293). The structural studies were complemented by density functional theory (DFT) calculations. DNA binding of 1–3 was spectrophotometrically studied. The DNA cleavage ability of 1–3 towards the supercoiled plasmid DNA (pBR322 DNA) was examined through gel electrophoresis. Compound 3 has the highest cytotoxic activity (IC50 = 3.5 μg mL−1) against HepG-2 among the investigated complexes and is non cytotoxic to noncancerous HEK-293. Complexes (1 and 2) exhibited toxicity to HEK-293 with IC50 values of 30.3 and 23.5 μg mL−1 in that order. While compound 1 showed antifungal activity against Cryptococcus neoformans, complex 2 exhibited its toxicity against Candida albicans.

Graphical abstract: DNA/lysozyme binding propensity and nuclease properties of benzimidazole/2,2′-bipyridine based binuclear ternary transition metal complexes

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Article information

DOI
https://doi.org/10.1039/C9RA07188A
Article type
Paper
Submitted
07 Sep 2019
Accepted
25 Sep 2019
First published
30 Sep 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 30879-30887

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DNA/lysozyme binding propensity and nuclease properties of benzimidazole/2,2′-bipyridine based binuclear ternary transition metal complexes

A. M. Mansour and M. S. Ragab, RSC Adv., 2019, 9, 30879 DOI: 10.1039/C9RA07188A

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