Issue 31, 2019
From the journal:

RSC Advances

Facile synthesis of 2-substituted benzo[b]furans and indoles by copper-catalyzed intramolecular cyclization of 2-alkynyl phenols and tosylanilines†

Zhouting Rong, ORCID logo *a   Kexin Gao,a   Lei Zhou,a   Jianyuan Lin*a  and  Guoying Qian*a  

* Corresponding authors

a College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, People's Republic of China
E-mail: zrong@zwu.edu.cn, linjianyuan@zwu.edu.cn, qiangy@zwu.edu.cn

Abstract

A catalytic amount of CuCl and Cs2CO3 was employed to synthesize a variety of 2-substituted benzo[b]furans and indoles by an intramolecular cyclization of 2-alkynyl phenols and tosylanilines. This protocol features mild conditions, high yields and broad substrate scope, which makes it a practical method for the synthesis of 2-substituted benzo[b]furans and indoles.

Graphical abstract: Facile synthesis of 2-substituted benzo[b]furans and indoles by copper-catalyzed intramolecular cyclization of 2-alkynyl phenols and tosylanilines

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Article information

DOI
https://doi.org/10.1039/C9RA01260E
Article type
Paper
Submitted
19 Feb 2019
Accepted
19 Apr 2019
First published
07 Jun 2019
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2019,9, 17975-17978

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Facile synthesis of 2-substituted benzo[b]furans and indoles by copper-catalyzed intramolecular cyclization of 2-alkynyl phenols and tosylanilines

Z. Rong, K. Gao, L. Zhou, J. Lin and G. Qian, RSC Adv., 2019, 9, 17975 DOI: 10.1039/C9RA01260E

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