Influence of nanomedicine mechanical properties on tumor targeting delivery

Zheng Li; Chen Xiao; Tuying Yong; Zifu Li; Lu Gan; Xiangliang Yang

doi:10.1039/C9CS00575G

Influence of nanomedicine mechanical properties on tumor targeting delivery

Zheng Li,†^a Chen Xiao,†^a Tuying Yong,†^a Zifu Li,

*^abc Lu Gan*^abc and Xiangliang Yang*^abc

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* Corresponding authors

^a National Engineering Research Center for Nanomedicine, College of Life Science and Technology, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, China
E-mail: zifuli@hust.edu.cn, lugan@hust.edu.cn, yangxl@hust.edu.cn

^b Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, China

^c Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medical, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, China

Abstract

Modulating nanomedicine mechanical properties for enhanced drug delivery to tumors has attracted increasing attention in the past few decades. In this tutorial review, we analyze the impact of nanomedicine mechanical properties on in vivo transport processes and highlight the most recent advances in drug delivery efficiency and antitumor efficacy. Typical nanoparticles that have been explored for this purpose since 2000 are summarized while the methods to tune and the techniques to characterize nanomedicine mechanical properties are introduced. In the end, challenges and perspectives on tailoring nanomedicine mechanical properties for tumor targeting delivery are discussed.

Article information

https://doi.org/10.1039/C9CS00575G

Article type

Tutorial Review

Submitted

18 Jan 2020

First published

26 Mar 2020

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Chem. Soc. Rev., 2020,49, 2273-2290

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Influence of nanomedicine mechanical properties on tumor targeting delivery

Z. Li, C. Xiao, T. Yong, Z. Li, L. Gan and X. Yang, Chem. Soc. Rev., 2020, 49, 2273 DOI: 10.1039/C9CS00575G

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Influence of nanomedicine mechanical properties on tumor targeting delivery

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