Issue 25, 2018, Issue in Progress
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RSC Advances

A nano-magnetic electrochemical sensor for the determination of mood disorder related substances†

Fernando H. Cincotto, ORCID logo *a   Daniel A. S. Carvalho,a   Thiago C. Canevari,b   Henrique E. Toma,c   Orlando Fatibello-Filho ORCID logo a  and  Fernando C. Moraes*a  

* Corresponding authors

a Chemistry Department, Federal University of São Carlos, São Carlos, SP, Brazil
E-mail: fernandocincotto@gmail.com, fcmoraes@ufscar.br

b Engineering School, Mackenzie Presbyterian University, São Paulo, SP, Brazil

c Institute of Chemistry, University of São Paulo, São Paulo, SP, Brazil

Abstract

The simultaneous electrochemical detection of mood disorder related substances, such as amitriptyline, melatonin and tryptophan, was successfully achieved by using a novel nano-magnetic electrochemical sensor design, encompassing Fe3O4 nanoparticles decorated with carbon quantum dots (MagNPs/Cdots). The magnetic composite was characterized using HR-TEM microscopy, XRD and Raman spectroscopy, and was applied onto a glassy carbon electrode using a miniature neodymium magnet. The determination of amitriptyline, melatonin and tryptophan was performed by monitoring oxidation promoted by MagNPs/Cdots in BR-buffer at pH 3.0, which proceeded according to well-defined differential pulse voltammetry peaks, with detection limits of 5.9, 4.4 and 4.2 nmol L−1, respectively. No significant interference was seen from biological interferents such as uric acid, ascorbic acid, dopamine, estriol and 17β-estradiol. The magnetic hybrid material was highly stable in solution, opening exciting opportunities for the development of low cost and practical electrochemical sensors for the determination of mood disorder related substances in real clinical samples.

Graphical abstract: A nano-magnetic electrochemical sensor for the determination of mood disorder related substances

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Article information

DOI
https://doi.org/10.1039/C8RA01857J
Article type
Paper
Submitted
02 Mar 2018
Accepted
03 Apr 2018
First published
16 Apr 2018
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2018,8, 14040-14047

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A nano-magnetic electrochemical sensor for the determination of mood disorder related substances

F. H. Cincotto, D. A. S. Carvalho, T. C. Canevari, H. E. Toma, O. Fatibello-Filho and F. C. Moraes, RSC Adv., 2018, 8, 14040 DOI: 10.1039/C8RA01857J

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