Issue 75, 2018
From the journal:

Chemical Communications

Target induced reconstruction of DNAzymatic amplifier nanomachines in living cells for concurrent imaging and gene silencing†

Jun-Jie Li,a   Wan-Ning Li,a   Wen-Fang Du,a   Meng-Mei Lv,a   Zhen-Kun Wu*a  and  Jian-Hui Jiang ORCID logo *a  

* Corresponding authors

a Institute of Chemical Biology and Nanomedicine, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China
E-mail: tomwu@hnu.edu.cn, jianhuijiang@hnu.edu.cn
Fax: +86-731-88822872
Tel: +86-731-88822577

Abstract

A novel DNAzymatic amplifier nanomachine that is reconstructed in response to an mRNA input has been developed to enable the functions of concurrent sensitive mRNA imaging and activatable gene therapy in living cells.

Graphical abstract: Target induced reconstruction of DNAzymatic amplifier nanomachines in living cells for concurrent imaging and gene silencing

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Article information

DOI
https://doi.org/10.1039/C8CC05832F
Article type
Communication
Submitted
18 Jul 2018
Accepted
24 Aug 2018
First published
25 Aug 2018

Chem. Commun., 2018,54, 10626-10629

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Target induced reconstruction of DNAzymatic amplifier nanomachines in living cells for concurrent imaging and gene silencing

J. Li, W. Li, W. Du, M. Lv, Z. Wu and J. Jiang, Chem. Commun., 2018, 54, 10626 DOI: 10.1039/C8CC05832F

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