SCHEDULED MAINTENANCE
Effect of polyethylene glycol on the antibacterial properties of polyurethane/carbon nanotube electrospun nanofibers
Abstract
The discovery of antibacterial functions for carbon nanotubes (CNT) has triggered great interest because of the excellent antibacterial properties of CNT. However, there are two obstacles, i.e., cell toxicity and CNT aggregation in a polymer matrix, which greatly limit the antibacterial application of CNT in medical devices. In this study, a facile, cost-effective, time-saving and environmentally friendly approach was proposed to impart the antibacterial property to thermoplastic polyurethane (TPU) electrospun nanofibers with CNT. The ultrasonication technique was explored to in situ anchor the CNT onto the TPU electrospun nanofibers to achieve the bactericidal property. This effectively circumvented the aggregation of CNT when the TPU/CNT electrospun nanofibers were prepared. In addition, the anchor preparation was efficient taking only 10 min to complete and it was also non-toxic because the green solvent ethanol was used as the dispersion solvent. PEG was chemically grafted onto the TPU (TPU-g-PEG) electrospun nanofibers through UV photo-graft polymerization. Although CNT exhibit a good bactericidal property, they could be toxic to human cells. Incorporation of PEG could not only effectively reduce the toxicity of CNT to the human cells but also decrease bacterial attachment. The TPU-g-PEG/CNT nanofibers exhibited excellent hemocompatibility, including suppression of red blood cell adhesion, and lower hemolysis ratios. Importantly, the as-prepared nanofibers had better antibacterial properties due to the bacterial resistance of the grafted PEG and the bactericidal effect of CNT. Our facile approach has significant potential for the infection-resistant wound dressing.
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