Bright and biocompatible AIE polymeric nanoparticles prepared from miniemulsion for fluorescence cell imaging

Zhihai Cao; Xiaoqin Liang; Hangnan Chen; Meng Gao; Zujin Zhao; Xiaolong Chen; Chang Xu; Gan Qu; Dongming Qi; Ben Zhong Tang

doi:10.1039/C6PY01079B

Bright and biocompatible AIE polymeric nanoparticles prepared from miniemulsion for fluorescence cell imaging†

Zhihai Cao,*^a Xiaoqin Liang,^a Hangnan Chen,^a Meng Gao,^b Zujin Zhao,*^b Xiaolong Chen,*^c Chang Xu,^a Gan Qu,^a Dongming Qi^a and Ben Zhong Tang^bd

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* Corresponding authors

^a Key Laboratory of Advanced Textile Materials and Manufacturing Technology and Engineering Research Center for Eco-Dyeing & Finishing of Textiles, Ministry of Education, Zhejiang Sci-Tech University, Hangzhou 310018, China
E-mail: zhcao@zstu.edu.cn

^b State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China
E-mail: mszjzhao@scut.edu.cn

^c NanoDrug Platform, Zhejiang California International NanoSystems Institute, Zhejiang University, Hangzhou 310058, China
E-mail: ndpzcni@zju.edu.cn

^d Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, China

Abstract

Aggregation-induced emission (AIE) polymeric nanoparticles (NPs) with a size of several tens of nanometers were successfully prepared by miniemulsion copolymerization of methyl methacrylate (MMA) with an AIE monomer, 1-allyl-1-methyl-2,3,4,5-tetraphenylsilole (AMTPS). The prepared AIE poly(MMA-co-AMTPS) NPs exhibited strong photoluminescence with high quantum yields. Promisingly, the brightness of AIE poly(MMA-co-AMTPS) NPs, which increased linearly with an increase in AMTPS content, could be accurately modulated via the AMTPS content in the range of 0–20 wt%. In vitro cell experiments indicated that the AIE poly(MMA-co-AMTPS) NPs were promising cell staining reagents with good biocompatibility and high photostability.

Polymer Chemistry

Bright and biocompatible AIE polymeric nanoparticles prepared from miniemulsion for fluorescence cell imaging†

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Bright and biocompatible AIE polymeric nanoparticles prepared from miniemulsion for fluorescence cell imaging

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