Issue 45, 2016, Issue in Progress
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RSC Advances

A new biosafe reactive oxygen species (ROS)-responsive nanoplatform for drug delivery

Qing Li,a   Yong Wen,a   Jie Wen,a   Yun-Peng Zhang,a   Xiao-Ding Xu,*b   Amanda Victorious,c   Ryan Zavitzc  and  Xin Xu*a  

* Corresponding authors

a School of Stomatology, Shandong University, Jinan, Shandong 250012, P. R. China
E-mail: xinxu@sdu.edu.cn
Fax: +86 531 8838292
Tel: +86 531 8838292

b Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China
E-mail: xd-xu@whu.edu.cn
Fax: +86 27 68754509
Tel: +86 27 68754509

c Department of Chemical Engineering, University of Waterloo, Waterloo N2L 3G1, Ontario, Canada

Abstract

A new ROS-cleavable diblock copolymer (Meo-PEG-TK-PLGA) was designed and prepared. This polymer can self-assemble into small-sized (<100 nm) nanoparticles (NPs), with hydrophilic PEG shells and hydrophobic PLGA cores. This new nanoplatform shows high stability, satisfactory drug loading ability, excellent ROS sensitivity and good compatibility resulting from the use of FDA-approved PEG and PLGA. When using these new NPs to load the anticancer drug doxorubicin (DOX) and incubate with oral cancer cell line (Cal27 cells), the NPs can efficiently escape from endosomes and enter into the cytoplasm. With the presence of intracelluar ROS to cleave TK-containing linker, the loaded DOX could be rapidly released and induce the apoptosis of Cal27 cells. The polymer presents great potential as a novel drug delivery platform for cancer chemotherapy.

Graphical abstract: A new biosafe reactive oxygen species (ROS)-responsive nanoplatform for drug delivery

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Article information

DOI
https://doi.org/10.1039/C5RA25913D
Article type
Paper
Submitted
04 Dec 2015
Accepted
30 Mar 2016
First published
19 Apr 2016

RSC Adv., 2016,6, 38984-38989

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A new biosafe reactive oxygen species (ROS)-responsive nanoplatform for drug delivery

Q. Li, Y. Wen, J. Wen, Y. Zhang, X. Xu, A. Victorious, R. Zavitz and X. Xu, RSC Adv., 2016, 6, 38984 DOI: 10.1039/C5RA25913D

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