Issue 107, 2015
From the journal:

RSC Advances

Stable single device multi-pore electrospraying of polymeric microparticles via controlled electrostatic interactions†

Chunchen Zhang,ab   Ming-Wei Chang,*ab   Zeeshan Ahmad,c   Weiwen Hu,d   Ding Zhaoab  and  Jing-Song Lia  

* Corresponding authors

a College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, P. R. China
E-mail: mwchang@zju.edu.cn

b Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Hangzhou, P. R. China

c Leicester School of Pharmacy, De Montfort, University, The Gateway, Leicester, UK

d College of Electrical Engineering, Zhejiang University, Hangzhou, P. R. China

Abstract

This work demonstrates a facile fabrication method to produce high throughput biodegradable microparticles (MPs) using a flute-like multi-pore emitter device in place of conventional single needle electrospraying capillaries. By manipulating the configuration of the emitter and the processing parameters, uniform microparticles are successfully sprayed in a single step for large-scale production. Furthermore, by manipulating individual spatial pore location various jet-bending interactions, which give rise to particle variations and irregularities, are overcome. Finally, findings correlate well with models reported by Hartman.

Graphical abstract: Stable single device multi-pore electrospraying of polymeric microparticles via controlled electrostatic interactions

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Article information

DOI
https://doi.org/10.1039/C5RA18482G
Article type
Communication
Submitted
09 Sep 2015
Accepted
12 Oct 2015
First published
12 Oct 2015

RSC Adv., 2015,5, 87919-87923

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Stable single device multi-pore electrospraying of polymeric microparticles via controlled electrostatic interactions

C. Zhang, M. Chang, Z. Ahmad, W. Hu, D. Zhao and J. Li, RSC Adv., 2015, 5, 87919 DOI: 10.1039/C5RA18482G

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