Issue 26, 2015
From the journal:

Organic & Biomolecular Chemistry

Catalyst-free direct decarboxylative coupling of α-keto acids with thiols: a facile access to thioesters†

Kelu Yan,a   Daoshan Yang,*a   Wei Wei,a   Jing Zhao,a   Yuanyuan Shuai,a   Laijin Tiana  and  Hua Wang*a  

* Corresponding authors

a The Key Laboratory of Life-Organic Analysis and Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Qufu Normal University, Qufu 273165, Shandong, P. R. China
E-mail: yangdaoshan@tsinghua.org.cn, huawang_qfnu@126.com

Abstract

A novel, efficient, and catalyst-free strategy has been initially developed for the construction of thioesters via the direct radical oxidative decarboxylation of α-keto acids with thiols, and the corresponding target products were obtained in moderate to good yields. It offers an alternative approach for the synthesis of useful diverse thioesters.

Graphical abstract: Catalyst-free direct decarboxylative coupling of α-keto acids with thiols: a facile access to thioesters

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Article information

DOI
https://doi.org/10.1039/C5OB00769K
Article type
Paper
Submitted
17 Apr 2015
Accepted
26 May 2015
First published
26 May 2015

Org. Biomol. Chem., 2015,13, 7323-7330

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Catalyst-free direct decarboxylative coupling of α-keto acids with thiols: a facile access to thioesters

K. Yan, D. Yang, W. Wei, J. Zhao, Y. Shuai, L. Tian and H. Wang, Org. Biomol. Chem., 2015, 13, 7323 DOI: 10.1039/C5OB00769K

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