Issue 58, 2014
From the journal:

RSC Advances

DNA-functionalized polystyrene particles and their controlled self-assembly

Rungsima Chollakup,a   Wirasak Smitthipong*a  and  Arkadiusz Chworosbc  

* Corresponding authors

a Kasetsart Agricultural and Agro-Industrial Product Improvement Institute (KAPI), Kasetsart University, 50 Ngam Wong Wan Rd., Chatuchak, Bangkok 10900, Thailand
E-mail: aapwss@ku.ac.th
Fax: +662 9405634
Tel: +662 9428604

b Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lodz, Poland
E-mail: achworos@cbmm.lodz.pl

c Department of Chemistry, University of California, Santa Barbara, USA

Abstract

DNA-functionalized polystyrene colloids and their thermodynamic characteristics are investigated here. This system is built on micro-sized polymer bids with different lengths of DNA spacer grafted onto the surface of the particles. Two types of DNA linkers were designed to create a bridge between complementary DNA-functionalized particles, to better understand the effect of the DNA sequence on an annealing temperature (Tm) of the aggregation. The disassembly of the polymeric scaffold based on DNA melting is in a good agreement with that calculated from the thermodynamic information. However, the length and the topology of the DNA spacer are important for the experimental melting point because of the effect of the directionality of the double-stranded DNA between the DNA-grafted particles and DNA linker.

Graphical abstract: DNA-functionalized polystyrene particles and their controlled self-assembly

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Article information

DOI
https://doi.org/10.1039/C4RA03825H
Article type
Paper
Submitted
26 Apr 2014
Accepted
01 Jul 2014
First published
01 Jul 2014

RSC Adv., 2014,4, 30648-30653

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DNA-functionalized polystyrene particles and their controlled self-assembly

R. Chollakup, W. Smitthipong and A. Chworos, RSC Adv., 2014, 4, 30648 DOI: 10.1039/C4RA03825H

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