Issue 9, 2009
From the journal:

Chemical Communications

A ratiometric fluorescent sensor with a large Stokes shift for imaging zinc ions in living cells†

Lin Xue,ac   Chun Liub  and  Hua Jiang*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
E-mail: hjiang@iccas.ac.cn

b State Key Laboratory of Fine Chemicals, Department of Chemical Engineering, Dalian University of Technology, 158 Zhongshan Road, Dalian, China

c Graduate School of Chinese Academy of Sciences, Beijing, China

Abstract

The ratiometric fluorescent sensor FQ1 based on furoquinoline has been designed and synthesized, and not only exhibits a large Stokes shift of 199 nm in a mixture of C2H5OH–H2O (v/v = 8 : 2, 10 mM Tris-HCl, pH = 7.3), but can selectively detect zinc ions in the presence of competing metal ions with a red-shift of 75 nm; moreover, cell stain experiments show that FQ1 can readily reveal a change in intracellular Zn2+.

Graphical abstract: A ratiometric fluorescent sensor with a large Stokes shift for imaging zinc ions in living cells

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Article information

DOI
https://doi.org/10.1039/B814501F
Article type
Communication
Submitted
20 Aug 2008
Accepted
18 Nov 2008
First published
24 Dec 2008

Chem. Commun., 2009, 1061-1063

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A ratiometric fluorescent sensor with a large Stokes shift for imaging zinc ions in living cells

L. Xue, C. Liu and H. Jiang, Chem. Commun., 2009, 1061 DOI: 10.1039/B814501F

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