Issue 3, 2002
From the journal:

Green Chemistry

Direct, efficient, solvent-free synthesis of 2-aryl-1,2,3,4-tetrahydroquinazolines

Waldo H. Correa,a   Stavroula Papadopoulos,a   Peta Radnidge,a   Brett A. Robertsa  and  Janet L. Scott*a  

* Corresponding authors

a Centre for Green Chemistry, P.O. Box 23, Monash University, Melbourne, Victoria, Australia
E-mail: janet.scott@sci.monash.edu.au

Abstract

2-Aryl-1,2,3,4-tetrahydroquinazolines are synthesised by direct reaction of 2-aminobenzylamine and benzaldehyde derivatives by mixing of the reagents either neat, or as an aqueous slurry. Excellent conversion of starting materials is achieved and no catalysts, derivatisation or auxiliary reagents are required to effect the conversion. Where reaction is sluggish or extent of conversion poor, application of gentle heating to achieve a melt phase results in rapid and clean conversion to the desired tetrahydroquinazoline product.

Graphical abstract: Direct, efficient, solvent-free synthesis of 2-aryl-1,2,3,4-tetrahydroquinazolines

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Article information

DOI
https://doi.org/10.1039/B202729C
Article type
Paper
Submitted
18 Mar 2002
First published
30 Apr 2002

Green Chem., 2002,4, 245-251

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Direct, efficient, solvent-free synthesis of 2-aryl-1,2,3,4-tetrahydroquinazolines

W. H. Correa, S. Papadopoulos, P. Radnidge, B. A. Roberts and J. L. Scott, Green Chem., 2002, 4, 245 DOI: 10.1039/B202729C

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