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Individual susceptibility to carcinogens

Oncogene volume 23, pages 6477–6483 (2004)Cite this article

Abstract

The contribution of polymorphisms in carcinogen metabolizing genes to overall cancer rates may vary widely between groups with differing allele frequencies and with varying levels of carcinogenic exposure. Their effects are modified by interactions with each other and with other genes, particularly those involved in DNA repair. Studies on the combined effects of particular polymorphisms on colorectal and other cancers, and also on intermediate markers such as DNA adduct formation, are discussed. Such susceptibility genes are of considerable scientific interest, but do not confer high enough risks to be clinically relevant.

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Acknowledgements

This paper has been made possible by a grant of the European Union (QLK4-1999-00927) and a grant from the Compagnia di San Paolo (Torino) and from the Associazione Italiana Per La Ricerca Sul Cancro. I am grateful to Seymour Garte, Emanuela Taioli and Giuseppe Matullo for comments.

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  1. Dipartimento di Scienze Biomediche e Oncologia Umana, Unit of Cancer Epidemiology, Torino, Italy

    Paolo Vineis

  2. Imperial College London, London, UK

    Paolo Vineis

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  1. Paolo Vineis
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Correspondence to Paolo Vineis.

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Vineis, P. Individual susceptibility to carcinogens. Oncogene 23, 6477–6483 (2004). https://doi.org/10.1038/sj.onc.1207897

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