Abstract
Connections between PML nuclear bodies (PML NBs) and DNA virus replication have been investigated from the earliest days of the molecular characterization of PML and associated proteins. It appears to be a general feature of nuclear-replicating DNA viruses that their parental genomes preferentially become associated with PML NBs, and that their initial sites of transcription and development of DNA replication centres are frequently juxtaposed to these domains or their remnants. In addition, regulatory proteins encoded by several DNA viruses associate with and sometimes cause catastrophic changes to PML NBs by a variety of mechanisms. These events can be correlated with the efficiency of viral infection and the functions of viral regulatory proteins, but the underlying molecular connections between PML NB function and viral infection remain poorly understood. This article reviews the latest developments in the interactions between PML NBs and herpesviruses, adenoviruses and papovaviruses.
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References
Adamson AL, Kenney S . 2001 J. Virol. 75: 2388–2399
Ahn JH, Brignole EJ, Hayward GS . 1998 Mol. Cell. Biol. 18: 4899–4913
Ahn JH, Hayward GS . 1997 J. Virol. 71: 4599–4613
Ahn JH, Hayward GS . 2000 Virology 274: 39–55
Ahn JH, Jang WJ, Hayward GS . 1999 J. Virol. 73: 10458–10471
Ahn JH, Xu Y, Jang WJ, Matunis MJ, Hayward GS . 2001 J. Virol. 75: 3859–3872
Anton LC, Schubert U, Bacik I, Princiotta MF, Wearsch PA, Gibbs J, Day PM, Realini C, Rechsteiner MC, Bennink JR, Yewdell JW . 1999 J. Cell Biol. 146: 113–124
Ballestas ME, Chatis PA, Kaye KM . 1999 Science 284: 641–644
Bastien N, McBride AA . 2000 Virology 270: 124–134
Bell P, Lieberman PM, Maul GG . 2000 J. Virol. 74: 11800–11810
Burkham J, Coen DM, Hwang CB, Weller SK . 2001 J. Virol. 75: 2353–2367
Burkham J, Coen DM, Weller SK . 1998 J. Virol. 72: 10100–10107
Carvalho T, Seeler JS, Ohman K, Jordan P, Pettersson U, Akusjarvi G, Carmo-Fonseca M, Dejean A . 1995 J. Cell Biol. 131: 45–56
Chelbi-Alix MK, de The H . 1999 Oncogene 18: 935–941
Cotter MA, Robertson ES . 1999 Virology 264: 254–264
Day PM, Roden RB, Lowry DR, Schiller JT . 1998 J. Virol. 72: 142–150
Desterro JM, Rodriguez MS, Hay RT . 1998 Mol. Cell. 2: 233–239
Doucas V, Ishov AM, Romo A, Juguilon H, Weitzman MD, Evans RM, Maul GG . 1996 Genes Dev. 10: 196–207
Everett RD . 1999 Trends Biochem. Sci. 24: 293–295
Everett RD . 2000a J. Virol. 74: 9994–10005
Everett RD . 2000b Bioessays 22: 761–770
Everett RD, Earnshaw WC, Findlay J, Lomonte P . 1999a EMBO J. 18: 1526–1538
Everett RD, Earnshaw WC, Pluta AF, Sternsdorf T, Ainsztein AM, Carmena M, Ruchaud S, Hsu WL, Orr A . 1999b J. Cell Sci. 112: 3443–3454
Everett RD, Freemont P, Saitoh H, Dasso M, Orr A, Kathoria M, Parkinson J . 1998a J. Virol. 72: 6581–6591
Everett RD, Lomonte P, Sternsdorf T, van Driel R, Orr A . 1999c J. Cell Sci. 112: 4581–4588
Everett RD, Maul GG . 1994 EMBO J. 13: 5062–5069
Everett RD, Meredith M, Orr A . 1999d J. Virol. 73: 417–426
Everett RD, Meredith M, Orr A, Cross A, Kathoria M, Parkinson J . 1997 EMBO J. 16: 1519–1530
Everett RD, Orr A, Preston CM . 1998b EMBO J. 17: 7161–7169
Everett RD, Preston CM, Stow ND . 1991 Functional and genetic analysis of the role of Vmw110 in herpes simplex virus replication. In Wagner EK (ed). The control of herpes simplex virus expression. CRC Press, Inc., Boca Raton, Fla
Fabunmi RP, Wigley WC, Thomas PJ, DeMartino GN . 2001 J. Cell Sci. 114: 29–36
Fields BN, Knipe DM, Howley PM . 1996 Virology, 3rd edn Lippincott-Raven, Philadelphia, PA
Freemont PS . 2000 Curr. Biol. 10: R84–R87
Halford WP, Schaffer PA . 2001 J. Virol. 75: 3240–3249
Heino P, Zhou J, Lambert PF . 2000 Virology 276: 304–314
Hobbs SE, Brough DE, Kovesdi I, DeLuca NA . 2001 J. Virol. 75: 3391–3403
Hofmann H, Floss S, Stamminger T . 2000 J. Virol. 74: 2510–2524
Hsu WL, Everett RD . 2001 J. Virol. 75: 3819–3831
Ishov AM, Maul GG . 1996 J. Cell Biol. 134: 815–826
Ishov AM, Sotnikov AG, Negorev D, Vladimirova OV, Neff N, Kamitani T, Yeh ET, Strauss JF, Maul GG . 1999 J. Cell Biol. 147: 221–234
Ishov AM, Stenberg RM, Maul GG . 1997 J. Cell Biol. 138: 5–16
Jiang WQ, Szekely L, Klein G, Ringertz N . 1996 Exp. Cell Res. 229: 289–300
Joazeiro CA, Weissman AM . 2000 Cell 102: 549–552
Kelly C, Van Driel R, Wilkinson GW . 1995 J. Gen. Virol. 76: 2887–2893
Korioth F, Maul GG, Plachter B, Stamminger T, Frey J . 1996 Exp. Cell Res. 229: 155–158
Lallemand-Breitenbach V, Zhu J, Puvion F, Koken MH, Honore N, Doubeikovsky A, Duprez E, Pandolfi PP, Puvion E, Freemont P, de The H . 2001 Experimental Medicine 193: 1361–1372
Lehman CW, Botchan MR . 1998 Proc. Natl. Acad. Sci. USA 95: 4338–4343
Lehming N, Le Saux A, Schuller J, Ptashne M . 1998 Proc. Natl. Acad. Sci. USA 95: 7322–7326
Leppard KN, Everett RD . 1999 J. Gen. Virol. 80: 997–1008
Li H, Leo C, Zhu J, Wu X, O'Neil J, Park EJ, Chen JD . 2000 Mol. Cell Biol. 20: 1784–1796
Li SJ, Hochstrasser M . 1999 Nature 398: 246–251
Lomonte P, Everett RD . 1999 J. Virol. 73: 9456–9467
Lomonte P, Sullivan KF, Everett RD . 2001 J. Biol. Chem. 276: 5829–5835
Lukonis CJ, Weller SK . 1997 J. Virol. 71: 2390–2399
Mattsson K, Pokrovskaja K, Kiss C, Klein G, Szekely L . 2001 Proc. Natl. Acad. Sci. USA 98: 1012–1017
Maul GG . 1998 Bioessays 20: 660–667
Maul GG, Everett RD . 1994 J. Gen. Virol. 75: 1223–1233
Maul GG, Guldner HH, Spivack JG . 1993 J. Gen. Virol. 74: 2679–2690
Maul GG, Ishov AM, Everett RD . 1996 Virology 217: 67–75
Maul GG, Negorev D, Bell P, Ishov AM . 2000 J. Struct. Biol. 129: 278–287
Mocarski ES, Kemble GW, Lyle JM, Greaves RF . 1996 Proc. Natl. Acad. Sci. USA 93: 11321–11326
Mossman KL, Saffran HA, Smiley JR . 2000 J. Virol. 74: 2052–2056
Muller S, Dejean A . 1999 J. Virol. 73: 5137–5143
Parkinson J, Everett RD . 2000 J. Virol. 74: 10006–10017
Parkinson J, Everett RD . 2001 J. Virol. 75: 5357–5362
Parkinson J, Lees-Miller SP, Everett RD . 1999 J. Virol. 73: 650–657
Plehn-Dujowich D, Bell P, Ishov AM, Baumann C, Maul GG . 2000 Chromosoma 109: 266–279
Preston CM . 2000 J. Gen. Virol. 81: 1–19
Seeler JS, Marchio A, Sitterlin D, Transy C, Dejean A . 1998 Proc. Natl. Acad. Sci. USA 95: 7316–7321
Sternsdorf T, Jensen K, Reich B, Will H . 1999 J. Biol. Chem. 274: 12555–12566
Swindle CS, Zou N, Van Tine BA, Shaw GM, Engler JA, Chow LT . 1999 J. Virol. 73: 1001–1009
Szekely L, Selivanova G, Magnusson KP, Klein G, Wiman KG . 1993 Proc. Natl. Acad. Sci. USA 90: 5455–5459
Tang Q, Bell P, Tegtmeyer P, Maul GG . 2000 J. Virol. 74: 9694–9700
Taylor JL, Unverrich D, O'Brien WJ, Wilcox KW . 2000 J. Interferon Cytokine Res. 20: 805–815
Torii S, Egan DA, Evans RA, Reed JC . 1999 EMBO J. 18: 6037–6049
Tsukamoto T, Hashiguchi N, Janicki SM, Tumbar T, Belmont AS, Spector DL . 2000 Nat. Cell. Biol. 2: 871–878
Wilkinson GW, Kelly C, Sinclair JH, Rickards C . 1998 J. Gen. Virol. 79: 1233–1245
Wu FY, Ahn JH, Alcendor DJ, Jang WJ, Xiao J, Hayward SD, Hayward GS . 2001 J. Virol. 75: 1487–1506
Wu H, Ceccarelli DF, Frappier L . 2000 EMBO Rep. 1: 140–144
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Everett, R. DNA viruses and viral proteins that interact with PML nuclear bodies. Oncogene 20, 7266–7273 (2001). https://doi.org/10.1038/sj.onc.1204759
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DOI: https://doi.org/10.1038/sj.onc.1204759
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