Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Paper
  • Published:

BRCA1 and cell signaling

Oncogene volume 19, pages 6152–6158 (2000)Cite this article

Abstract

The breast cancer and ovarian cancer susceptibility gene BRCA1 encodes a nucleoprotein whose mutations or aberrant expression is associated with both inherited and sporadic cancers. Studies over the last 6 years have suggested that BRCA1 may function as a scaffold in the assembly of a multi-protein complex, which plays a role in gene transcription, DNA damage repair, and transcription-coupled DNA damage repair. In this review, we discuss the implications drawn from the studies of BRCA1-interacting proteins and the cellular signaling pathways that may be involved in controlling the functions of BRCA1.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  • Abbott DW, Thompson ME, Robinson-Benion C, Tomlinson G, Jensen RA and Holt JT. . 1999 J. Biol. Chem. 274: 18808–18812.

  • Amundson SA, Zhan Q, Penn LZ and Fornace Jr AJ. . 1998 Oncogene 17: 2149–2154.

  • Anderson SF, Schlegel BP, Nakajima T, Wolpin ES and Parvin JD. . 1998 Nat. Genet 19: 254–256.

  • Aprelikova ON, Fang BS, Meissner EG, Cotter S, Campbell M, Kuthiala A, Bessho M, Jensen RA and Liu ET. . 1999 Proc. Natl. Acad. Sci. USA 96: 11866–11871.

  • Bennett LM, Haugen-Strano A, Cochran C, Brownlee HA, Fiedorek Jr FT and Wiseman RW. . 1995 Genomics 29: 576–581.

  • Bischoff JR, Anderson L, Zhu Y, Mossie K, Ng L, Souza B, Schryver B, Flanagan P, Clairvoyant F, Ginther C, Chan CS, Novotny M, Slamon DJ and Plowman GD. . 1998 EMBO J. 17: 3052–3065.

  • Chapman MS and Verma IM. . 1996 Nature 382: 678–679.

  • Chen CF, Li S, Chen Y, Chen PL, Sharp ZD and Lee WH. . 1996 J. Biol. Chem. 271: 32863–32868.

  • Chen J, Silver DP, Walpita D, Cantor SB, Gazdar AF, Tomlinson G, Couch FJ, Weber BL, Ashley T, Livingston DM and Scully R. . 1998 Mol. Cell. 2: 317–328.

  • Chen Y, Chen CF, Riley DJ, Allred DC, Chen PL, Von Hoff D, Osborne CK and Lee WH. . 1995 Science 270: 789–791.

  • Constance CM, Morgan JIT and Umek RM. . 1996 Mol. Cell. Biol. 16: 3878–3883.

  • Cortez D, Wang Y, Qin J and Elledge SJ. . 1999 Science 286: 1162–1166.

  • Evans E, Sugawara N, Haber JE and Alani E. . 2000 Mol. Cell. 5: 789–799.

  • Fan S, Wang J, Yuan R, Ma Y, Meng Q, Erdos MR, Pestell RG, Yuan F, Auborn KJ, Goldberg ID and Rosen EM. . 1999 Science 284: 1354–1356.

  • Felsher DW and Bishop JM. . 1999 Proc. Natl. Acad. Sci. USA 96: 3940–3944.

  • Felsher DW, Zetlerberg A, Zhu J, Tlsty T and Bishop JM. . 2000 Proc. Natl. Acad. Sci. USA 97: 10544–10548.

  • Fishel R. . 1998 Genes Dev. 12: 2096–2101.

  • Fishel R and Wilson T. . 1997 Curr. Opin. Genet. Dev. 7: 105–113.

  • Futreal PA, Liu Q, Shattuck D, Cochran C, Harshman K, Tavtigian S, Bennett LM, Haugen-Strano A, Swensen J, Miki Y, Eddington K, McClure M, Frye C, Weaver-Feldhaus J, Ding W, Gholami Z, Soederkvist P, Terry L, Jhanwar S, Berchuck A, Iglehart JD, Marks J, Ballinger DG, Barrett JC, Skolnick MH, Kamb A and Roger W. . 1994 Science 266: 120–122.

  • Gatei M, Scott SP, Filippovitch I, Soronika N, Lavin MF, Weber B and Khanna KK. . 2000 Cancer Res. 60: 3299–3304.

  • Gowen LC, Avrutskaya AV, Latour AM, Koller BH and Leadon SA. . 1998 Science 281: 1009–1012.

  • Gowen LC, Johnson BL, Latour AM, Sulik KK and Koller BH. . 1996 Nat. Genet. 12: 191–194.

  • Gradia S, Acharya S and Fishel R. . 1997 Cell 91: 995–1005.

  • Gradia S, Acharya S and Fishel R. . 2000 J. Biol. Chem. 275: 3922–3930.

  • Gradia S, Subramanian D, Wilson T, Acharya S, Makhov A, Griffith J and Fishel R. . 1999 Mol. Cell. 3: 255–261.

  • Haber JE. . 1998 Cell 95: 583–586.

  • Hakem R, de la Pompa JL, Sirard C, Mo R, Woo M, Hakem A, Wakeham A, Potter J, Reitmair A, Billia F, Firpo E, Hui CC, Roberts J, Rossant J and Mak TW. . 1996 Cell 85: 1009–1023.

  • Harkin DP, Bean JM, Miklos D, Song YH, Truong VB, Englert C, Christians FC, Ellisen LW, Maheswaran S, Oliner JD and Haber DA. . 1999 Cell 97: 575–586.

  • Holt JT, Thompson ME, Szabo C, Robinson-Benion C, Arteaga CL, King MC and Jensen RA. . 1996 Nat. Genet. 12: 298–302.

  • Hsu LC and White RL. . 1998 Proc. Natl. Acad. Sci. USA 95: 12983–12988.

  • Hu YF, Hao ZL and Li R. . 1999 Genes. Dev. 13: 637–642.

  • Jensen DE, Proctor M, Marquis ST, Gardner HP, Ha SI, Chodosh LA, Ishov AM, Tommerup N, Vissing H, Sekido Y, Minna J, Borodovsky A, Schultz DC, Wilkinson KD, Maul GG, Barlev N, Berger SL, Prendergast GC and Rauscher III FJ. . 1998 Oncogene 16: 1097–1112.

  • Jensen DE and Rauscher III FJ. . 1999 Ann. NY. Acad. Sci. 886: 191–194.

  • Jin S, Zhao H, Fan F, Blanck P, Fan W, Colchagie AB, Fornace Jr AJ and Zhan Q. . 2000 Oncogene 19: 4050–4057.

  • Jin Y, Xu XL, Yang MC, Wei F, Ayi TC, Bowcock AM and Baer R. . 1997 Proc. Natl. Acad. Sci. USA 94: 12075–12080.

  • Kleiman FE and Manley JL. . 1999 Science 285: 1576–1579.

  • Leadon SA and Avrutskaya AV. . 1997 Cancer Res. 57: 3784–3791.

  • Li LH, Nerlov C, Prendergast G, MacGregor D and Ziff EB. . 1994 EMBO J. 13: 4070–4079.

  • Li S, Chen PL, Subramanian T, Chinnadurai G, Tomlinson G, Osborne CK, Sharp ZD and Lee WH. . 1999 J. Biol. Chem. 274: 11334–11338.

  • Liu CY, Flesken-Nikitin A, Li S, Zeng Y and Lee WH. . 1996 Genes Dev. 10: 1835–1843.

  • MacLachlan TK, Somasundaram K, Sgagias M, Shifman Y, Muschel RJ, Cowan KH and El-Deiry WS. . 2000 J. Biol. Chem. 275: 2777–2785.

  • Marhin WW, Chen S, Facchini LM, Fornace Jr AJ and Penn LZ. . 1997 Oncogene 14: 2825–2834.

  • McCormack SJ, Weaver Z, Deming S, Natarajan G, Torri J, Johnson MD, Liyanage M, Ried T and Dickson RB. . 1998 Oncogene 16: 2755–2766.

  • Merajver SD, Pham TM, Caduff RF, Chen M, Poy EL, Cooney KA, Weber BL, Collins FS, Johnston C and Frank TS. . 1995 Nat. Genet. 9: 439–443.

  • Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W, Bell R, Rosenthal J, Hussey C, Tran T, McClure M, Frye C, Hattier T, Phelps R, Haugen-Strano A, Katcher H, Yakumo K, Gholami Z, Shaffer D, Stone S, Bayer S, Wray C, Bodgen R, Dayananth P, Ward J, Tonin P, Narod S, Bristow P, Norris FH, Helvering L, Morrison P, Rosteck P, Lai M, Barrett, JC, Lewis C, Neuhausen S, Cannon-Albright L, Goldgar D, Wiseman R, Kamb, A and Skolnick MH. . 1994 Science 266: 66–71.

  • Monteiro AN, August A and Hanafusa H. . 1996 Proc. Natl. Acad. Sci. USA 93: 13595–13599.

  • Monteiro AN, August A and Hanafusa H. . 1997 Am. J. Hum. Genet. 61: 761–762.

  • Moynahan ME, Chiu JW, Koller BH and Jasin M. . 1999 Mol. Cell. 4: 511–518.

  • Ouchi T, Monteiro AN, August A, Aaronson SA and Hanafusa H. . 1998 Proc. Natl. Acad. Sci. USA 95: 2302–2306.

  • Pao GM, Janknecht R, Ruffner H, Hunter T and Verma IM. . 2000 Proc. Natl. Acad. Sci. USA 97: 1020–1025.

  • Paques F and Haber JE. . 1999 Microbiol. Mol. Biol. Rev. 63: 349–404.

  • Ruffner H, Jiang W, Craig AG, Hunter T and Verma IM. . 1999 Mol. Cell. Biol. 19: 4843–4854.

  • Ruffner H and Verma IM. . 1997 Proc. Natl. Acad. Sci. USA 94: 7138–7143.

  • Russell PA, Pharoah PD, De Foy K, Ramus SJ, Symmonds I, Wilson A, Scott I, Ponder BA and Gayther SA. . 2000 Int. J. Cancer 87: 317–321.

  • Schlegel BP, Green VJ, Ladias JA and Parvin JD. . 2000 Proc. Natl. Acad. Sci. USA 97: 3148–3153.

  • Scully R, Anderson SF, Chao DM, Wei W, Ye L, Young RA, Livingston DM and Parvin JD. . 1997a Proc. Natl. Acad. Sci. USA 94: 5605–5610.

  • Scully R, Chen J, Ochs RL, Keegan K, Hoekstra M, Feunteun J and Livingston DM. . 1997b Cell 90: 425–435.

  • Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T and Livingston DM. . 1997c Cell 88: 265–275.

  • Scully R, Ganesan S, Vlasakova K, Chen J, Socolovsky M and Livingston DM. . 1999 Mol. Cell. 4: 1093–1099.

  • Shao N, Chai YL, Shyam E, Reddy P and Rao VN. . 1996 Oncogene 13: 1–7.

  • Somasundaram K, Zhang H, Zeng YX, Houvras Y, Peng Y, Wu GS, Licht JD, Weber BL and El-Deiry WS. . 1997 Nature 389: 187–190.

  • Takekawa M and Saito H. . 1998 Cell 95: 521–530.

  • Terada Y, Tatsuka M, Suzuki F, Yasuda Y, Fujita S and Otsu M. . 1998 EMBO J. 17: 667–676.

  • Thompson ME, Jensen RA, Obermiller PS, Page DL and Holt JT. . 1995 Nat. Genet. 9: 444–450.

  • Tirkkonen M, Johannsson O, Agnarsson BA, Olsson H, Ingvarsson S, Karhu R, Tanner M, Isola J, Barkardottir RB, Borg A and Kallioniemi OP. . 1997 Cancer Res. 57: 1222–1227.

  • Toft NJ, Winton DJ, Kelly J, Howard LA, Dekker M, te Riele H, Arends MJ, Wyllie AH, Margison GP and Clarke AR. . 1999 Proc. Natl. Acad. Sci. USA 96: 3911–3915.

  • Tomlinson GE, Chen TT, Stastny VA, Virmani AK, Spillman MA, Tonk V, Blum JL, Schneider NR, Wistuba II, Shay JW, Minna JD and Gazdar AF. . 1998 Cancer Res. 58: 3237–3242.

  • Wang Q, Zhang H, Kajino K and Greene MI. . 1998 Oncogene 17: 1939–1948.

  • Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ and Qin J. . 2000 Genes Dev. 14: 927–939.

  • Weaver ZA, McCormack SJ, Liyanage M, du Manoir S, Coleman A, Schrock E, Dickson RB and Ried T. . 1999 Genes Chromosomes Cancer 25: 251–260.

  • Wong AK, Ormonde PA, Pero R, Chen Y, Lian L, Salada G, Berry S, Lawrence Q, Dayananth P, Ha P, Tavtigian SV, Teng DH and Bartel PL. . 1998 Oncogene 17: 2279–2285.

  • Wu LC, Wang ZW, Tsan JT, Spillman MA, Phung A, Xu XL, Yang MC, Hwang LY, Bowcock AM and Baer R. . 1996 Nat. Genet. 14: 430–440.

  • Xu X, Weaver Z, Linke SP, Li C, Gotay J, Wang XW, Harris CC, Ried T and Deng CX. . 1999 Mol. Cell. 3: 389–395.

  • Yarden RI and Brody LC. . 1999 Proc. Natl. Acad. Sci. USA 96: 4983–4988.

  • Yu X and Baer R. . 2000 J. Biol. Chem. 275: 18541–18549.

  • Yu X, Wu LC, Bowcock AM, Aronheim A and Baer R. . 1998 J. Biol. Chem. 273: 25388–25392.

  • Zhang H, Richards B, Wilson T, Lloyd M, Cranston A, Thorburn A, Fishel R and Meuth M. . 1999 Cancer Res. 59: 3021–3027.

  • Zhang H, Somasundaram K, Peng Y, Tian H, Bi D, Weber BL and El-Deiry WS. . 1998 Oncogene 16: 1713–1721.

  • Zhang H, Wang Q, Kajino K and Greene MI. . 2000 DNA Cell. Biol. 19: 253–263.

  • Zhang HT, Zhang X, Zhao HZ, Kajino Y, Weber BL, Davis JG, Wang Q, O'Rourke DM, Zhang HB, Kajino K and Greene MI. . 1997 Oncogene 14: 2863–2869.

  • Zheng W, Luo F, Lu JJ, Baltayan A, Press MF, Zhang ZF and Pike MC. . 2000 Gynecol. Oncol. 76: 294–300.

  • Zhong Q, Chen CF, Li S, Chen Y, Wang CC, Xiao J, Chen PL, Sharp ZD and Lee WH. . 1999 Science 285: 747–750.

  • Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, Brinkley BR and Sen S. . 1998 Nat. Genet. 20: 189–193.

Download references

Acknowledgements

This work is supported by the Abramson Family Institute for Cancer Research.

Author information

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, Pennsylvania, USA

    Qiang Wang, Hongtao Zhang & Mark I Greene

  2. Department of Microbiology and Immunology, Genetics and Molecular Biology Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, Pennsylvania, USA

    Richard Fishel

Authors
  1. Qiang Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hongtao Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Richard Fishel
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Mark I Greene
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, Q., Zhang, H., Fishel, R. et al. BRCA1 and cell signaling. Oncogene 19, 6152–6158 (2000). https://doi.org/10.1038/sj.onc.1203974

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.onc.1203974

Keywords

This article is cited by

Search

Advanced search

Quick links