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Association between the 102T/C polymorphism of serotonin-2A receptor gene and schizophrenia among south Indians

Molecular Psychiatry volume 7, pages 540–541 (2002)Cite this article

SIR – Aberrations in the functioning of the serotonergic system have been implicated in many psychiatric illnesses such as depression, aggressive behavior, eating disorders, affective disorders and psychosis.1 The 102T/C polymorphism of the 5-HT2A receptor is encoded by two alleles, allele 1(TCT) and allele 2 in which C replaces T in the 102nd position (TCC). Allele 2 has a site for the restriction enzyme MspI.2 Based on these alleles individuals can be genotyped as 1–1 (homozygous for allele 1), 1–2 (heterozygote) and 2–2 (homozygous for allele 2). This polymorphism has been reported to be associated with schizophrenia in a number of studies in various ethnic groups around the world.3,4 This is the first time that this polymorphism is being studied in a south Indian population with regard to schizophrenia.

A large collaborative study of a European Caucasian population reported an attributable risk of 35% of developing the disease in individuals possessing allele 2.5 However there are also studies refuting this association which may be due to ethnic differences in the genetic susceptibility to schizophrenia.6,7,8,9 Some studies have shown an association between this polymorphism and response to antipsychotic medication.10,11,12

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Authors and Affiliations

  1. Centre for Biological Psychiatry and Advanced Biology, Indira Health Home, Road 5, Banjara Hills, Hyderabad, 34, India

    U S Araga

  2. School of Biotechnology, Jawaharlal Nehru Technological University, Mahavir Marg, Hyderabad, India

    M L Narasu

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  1. U S Araga
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  2. M L Narasu
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Correspondence to U S Araga.

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Araga, U., Narasu, M. Association between the 102T/C polymorphism of serotonin-2A receptor gene and schizophrenia among south Indians. Mol Psychiatry 7, 540–541 (2002). https://doi.org/10.1038/sj.mp.4001039

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