Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Rapid Communication
  • Published:

Chromosome abnormalities of the short arm of chromosome 12 in hematopoietic malignancies: a report including three novel translocations involving the TEL/ETV6 gene

Leukemia volume 11, pages 1400–1403 (1997)Cite this article

Abstract

A wide variety of abnormalities of the short arm of chromosome 12 has been reported in hematologic malignancies. The most frequent rearrangements result from t(12;21)(p13;q22) of childhood acute lymphoblastic leukemia, a translocation cryptic when leukemic cells are analyzed with chromosome banding techniques. This translocation results in a fusion of the TEL/ETV6 and AML1 genes. In this report, examples of rearrangements of 12p are presented. Study of two complex chromosome abnormalities associated with t(12;21) emphasizes the importance of using FISH in detection of such translocations. Three novel translocations involving the TEL/ETV6 gene localized on 12p13 are also reported: t(X;12)(q28;p13), t(1;12)(q21;p13), and t(9;12)(p23-24;p13). Finally, the presentation of two translocations with breakpoints located centromeric to TEL/ETV6 highlights the not uncommon involvement of genes other than TEL/ETV6 on 12p.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Unité INSERM U 301 and SD 401 No. 301 CNRS, Institut de Génétique Moléculaire, Paris, France

    R Berger, M Le Coniat, V Lacronique & O Bernard

  2. Laboratoire Central d’Hématologie, Hôpital Saint Louis, Paris, France

    M-T Daniel

  3. Laboratoire de Cytogénétique, Centre Hospitalier Régional de Brest, France

    M Lessard

  4. Service d’Hématologie, Centre Hospitalier Régional de Brest, France

    C Berthou

  5. Center for Human Genetics, University of Leuven, Belgium

    P Marynen

Authors
  1. R Berger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M Le Coniat
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V Lacronique
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M-T Daniel
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M Lessard
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C Berthou
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. P Marynen
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. O Bernard
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Berger, R., Le Coniat, M., Lacronique, V. et al. Chromosome abnormalities of the short arm of chromosome 12 in hematopoietic malignancies: a report including three novel translocations involving the TEL/ETV6 gene. Leukemia 11, 1400–1403 (1997). https://doi.org/10.1038/sj.leu.2400785

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2400785

Keywords

This article is cited by

Search

Advanced search

Quick links