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Sir,
We read with interest the recently published article by Dinakaran,1 raising concerns about the quality of processed ophthalmic instruments and the presence of foreign material on the surface of these instruments.
Despite close external inspection of the instruments prior to introduction into the eye, unwanted foreign material may still be retained within fine-bore instruments and enter the eye during surgery. Dinakaran's study1 and our observation2 do show that foreign debris may be introduced into the eye inadvertently. We have highlighted this issue, where unidentified foreign objects (UFOs) were observed in the clear corneal phacoemulsification wound.2 Two types of UFOs, reflectile metallic looking (Figure 1, left) and fibrillary appearing (Figure 1, right), were mainly noted. However, no case of persistent intraocular inflammation associated with UFOs has been reported and the visual outcome remained unaffected in our patients.
Dunbar et al3 have reported deposition of intraocular metallic fragments from the phacoemulsification probe. Debris (metallic and nonmetallic) from the microkeratomes, deposited at the corneal flap interface, has been reported after LASIK, which may be associated with diffuse lamellar keratitis.4,5 The static forces and viscoelastic smeared instrument tips may attract the fibrillary material from the drapes used to cover the instrument trolley and the patient. Organic debris and cellular material deposited on the reusable ophthalmic instruments during phacoemulsification may interfere with the process of sterilization.6 The long-term outcome of the UFOs in the eye is not clear. Transmission of variant Creutzfeldt–Jakob disease (vCJD) remains the major cause of concern in ophthalmic practice.7 Conventional sterilization techniques fail to disinfect the agents of prion diseases. The risk of transmission of prions can be reduced by physically removing the traces of organic material from the instruments before the recommended decontamination process.7
It is advisable that microsurgical instruments are cleaned thoroughly and washed immediately at the end of each surgery by the theatre staff, before organic matter dries within and on the surfaces of the reusable instruments, and then despatched for sterilization. Further work is needed to examine the prevalence, composition, and surgical outcomes in patients with UFOs following intraocular surgery. Disposable instruments for intraocular surgery may be one solution in reducing the introduction of UFOs into the eye and this approach would reduce the risk of vCJD transmission.
References
Dinakaran S, Kayarkar VV . Debris on processed ophthalmic instruments: a cause for concern. Eye 2002; 16(3): 281–284.
Wadood AC, Dhillon B . Clear corneal phacowound UFOs. J Cataract Refract Surg (in press).
Dunbar CM, Goble RR, Gregory DW, Church WC . Intraocular deposition of metallic fragments during phacoemulsification: possible causes and effects. Eye 1995; 9(Part 4): 434–436.
Kaufman SC, Maitchouk DY, Chiou AG, Beuerman RW . Interface inflammation after laser in situ keratomileusis. Sands of the Sahara syndrome. J Cataract Refract Surg 1998; 24(12): 1589–1593.
Pisella PJ, Auzerie O, Bokobza Y, Debbasch C, Baudouin C . Evaluation of corneal stromal changes in vivo after laser in situ keratomileusis with confocal microscopy. Ophthalmology 2001; 108(10): 1744–1750.
Miller CH . Cleaning, sterilization and disinfection: basics of microbial killing for infection control. J Am Dent Assoc 1993; 124(1): 48–56.
Lueck CJ, McIlwaine GG, Zeidler M . Creutzfeldt–Jakob disease and the eye. I. Background and patient management. Eye 2000; 14(Part 3A): 263–290.
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None of the authors or department has any proprietary or commercial interest related to the products or instruments described in this article.
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Wadood, A., Dhillon, B. Debris on processed ophthalmic instruments: a cause for concern. Eye 17, 453–454 (2003). https://doi.org/10.1038/sj.eye.6700358
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DOI: https://doi.org/10.1038/sj.eye.6700358