Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Diseases

Hematopoietic stem cell transplantation for autoimmune diseases in developing countries: current status and future prospectives

Summary:

In this paper we present preliminary results of hematopoietic stem cell transplantation for autoimmune diseases in Brazil and China. Chinese experience transplanting lupus is significant and the Brazilian experience with several autoimmune diseases is growing. We discuss peculiar conditions in developing countries which could affect the results, and future prospectives for the organization of phase III randomized trials in those countries.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Johnson AE, Cavalcanti FS, Gordon C et al. Cross-sectional analysis of differences between patients with systemic lupus erythematosus in England, Brazil and Sweden. Lupus 1994; 3: 501–506.

    Article  CAS  Google Scholar 

  2. Voltarelli JC, Stracieri ABPL . Aspectos imunológicos dos transplantes de células tronco hematopoéticas (Immunological aspects of haematopoietic stem cell transplantation). Medicina (Ribeirão Preto), 2000; 33: 443–462.

    Article  Google Scholar 

  3. Medeiros CR, Bitencourt MA, Zanis-Neto J, Pasquini R . Busulfan and cyclophosphamide (Bu+Cy) as conditioning regimen to transfused patients (pts) younger than 20 years old treated with bone marrow transplantation. Blood 1998; 92: 135a.

    Google Scholar 

  4. Ferreira E, Ribeiro A, Bacal NS et al. Transplante de células tronco periféricas autólogas no tratamento de doença auto-imune: Remissão completa da anemia hemolítica por aglutininas a frio e concomitante vasculite (Autologous peripheral blood haematopoietic stem cell transplantation in the treatment of an autoimmune disease: complete remission of cold agglutinin hemolytic anaemia and concomitant vasculitis). Bol Soc Bras Hematol Hematol 1996; 18 (Suppl): 191.

    Google Scholar 

  5. Voltarelli JC . Haematopoietic stem cell transplantation for autoimmune diseases in Brazil. Comment status and future prospectives. Rev Bras Hematol Hemoter 2002; 24: 206–211.

    Google Scholar 

  6. Traynor AE, Schroeder J, Rosa RM et al. Treatment of severe systemic lupus erythematosus with high-dose therapy and hematopoietic stem cell transplantation: a phase I study. Lancet 2000; 356: 701–707.

    Article  CAS  Google Scholar 

  7. Comi G, Kappos L, Clanet M et al. Guidelines for autologous and marrow stem cell transplantation in multiple sclerosis: a consensus report written on behalf of the European Group for Blood and Marrow Transplantation and the European Charcot Foundation. J Neurol 2000; 247: 376–382.

    Article  CAS  Google Scholar 

  8. Anderlini P, Giralt S, Andersson B et al. Allogeneic stem cell transplantation with fludarabine-based, less intensive conditioning regimens as adoptive immunotherapy in advanced Hodgkin's disease. Bone Marrow Transplant 2000; 26: 615–620.

    Article  CAS  Google Scholar 

  9. White B, Moore WC, Wigley FM et al. Cyclophosphamide is associated with pulmonary function and survival benefit in patients with scleroderma and alveolitis. Ann Intern Med 2000; 132: 947–954.

    Article  CAS  Google Scholar 

  10. Ouyang J, Sun LY, Yang YG et al. A pilot study in treatment of systemic lupus erythematosus by autologous bone marrow transplant. Chin J Intern Med 2001; 40: 229–231.

    CAS  Google Scholar 

  11. Zhao J, Fu Y, Peng X . Autologous hematopoietic stem cell transplantation in the treatment of systemic lupus erythematosus. Bone Marrow Transplant 2002; 29 (Suppl 2): S15.

    Google Scholar 

  12. Fassas A, Anagnostopoulos A, Kazis A et al. Autologous stem cell transplantation in progressive multiple sclerosis – an interim analysis of efficacy. J Clin Immunol 2000; 20: 24–30.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by FAPESP-CEPID, FUNDHERP, FAEPA-HCFMRP-USP and CNPq in Brazil, and by the Teaching and Research Affairs of Jiangsu Provincial Department of Health and Nanjing Municipal Bureau of Health in China.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to J C Voltarelli.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Voltarelli, J., Ouyang, J. Hematopoietic stem cell transplantation for autoimmune diseases in developing countries: current status and future prospectives. Bone Marrow Transplant 32 (Suppl 1), S69–S71 (2003). https://doi.org/10.1038/sj.bmt.1703947

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1703947

Keywords

This article is cited by

Search

Quick links