Factors influencing delay in malaria treatment seeking at selected public health facilities in South Gonder, Ethiopia

Early and prompt treatment-seeking for malaria is necessary to reduce the progression of the disease to its severe forms and the associated mortality. Various studies have indicated that treatments sought for malaria were not always within the recommended timeframe. Therefore, this study aims to assess factors influencing delay in malaria treatment seeking at public health facilities in South Gonder, Ethiopia. An unmatched case–control study was conducted among 322 individuals, comprising 161 cases and 161 controls, who were randomly selected malaria patients visiting public health facilities in South Gonder District, Ethiopia, from May 20/2022 to June 25/2022. An interviewer-administered questionnaire was used to collect data, which were subsequently cleaned and entered into Epi data. Descriptive statistics were performed, and variables with a p-value of ≤ 0.25 from the bivariate analysis were included in a multivariable logistic regression model. Significant variables with a p-value of < 0.05 were retained in the multivariable model. Patients who were unable to read and write [AOR = 3.47 (1.01–11.9)], fear of side effects of malaria treatment drugs [AOR = 1.89 (1.04–3.42)], lack of access to health education malaria disease and its treatment [AOR = 1.93 (1.02–3.65)], lack of transportation access [AOR = 4.70 (1.73–12.7)], not membership of community-based health insurance [AOR = 2.5 (1.3–4.82)] and lack of confidence on malaria care health facility providing [AOR = 2.14 (1.06–4.29)], were found to be determinants of treatment-seeking delay among malaria patients. In Summary, this study revealed significant associations between delays in seeking malaria treatment and factors such as educational status (those who were unable to read and write), malaria drug side effects, health education on malaria, transportation access, CBHI membership, and confidence in health malaria care. it is recommended that targeted interventions and awareness campaigns be implemented to address these determinants, promoting prompt and effective malaria treatment-seeking behavior in the studied population.


Inclusion and exclusion criteria
All confirmed malaria patients for Plasmodium species by blood film (Bf) or rapid diagnostic test (RDT) enrolled in the study were included in the study.While those who were critically ill were excluded from the study.

Sampling method and sample size determination
The sample size was determined by using the double population proportion formula for the case-control study in Epi-info 7.0 stat calc.The calculation was computed by taking three variables; the presence of side effects, knowledge of malaria, and distance of the health facility which are significantly associated with treatment-seeking delay in most studies.The final sample size was calculated by using the assumption of "presence of side effect" with the odds ratio of 4.96, the percent of controls exposed at 2.6%, the percent of cases exposed at 11.7% with a 95% confidence interval, power being 80%, case to control the ratio of 1:1 and by adding 10% nonresponse rate 20 .The total number of malaria patients was 17,622 from public health facilities.The study's ultimate sample comprised 322 participants, evenly divided into 161 cases and 161 controls at a one-to-one ratio.Both cases and controls were chosen separately through a systematic random sampling method.Cases were initially selected using a lottery, and subsequently, every fourth interval was chosen, as illustrated below.(Table 1).
Ninety-six public health facilities exist in South Gonder District, and for participant selection, nine were chosen randomly through a lottery method.This approach ensured an equal opportunity for all facilities, maintaining a fair and unbiased selection process.Cases were included by using a systematic random sampling technique by calculating the sampling interval for cases based on the average monthly cash flow of each health facility while controls were selected as cases were enrolled.
The Kth (K = 4) value was determined for both cases and controls; it was done separately by dividing the patient flow by sample size (the total malaria patient flow of South Gonder District of month June 2013 E.C was 1288 from the data that was collected from each facility.The study subject was selected by using systematic random sampling techniques after a laboratory request was done and when patients those positive for any species of Plasmodium, they were eligible and were moved to a private room for an interview until the total required sample size was obtained.

Knowledge about malaria
Assessed by ten knowledge assessment questions and those who scored 70% and more were considered as having adequate knowledge and those who scored less than 70% on knowledge assessment questions were considered as having inadequate knowledge 24 .

Timely treatment-seeking
This is a treatment sought for symptoms of malaria within 24 h of the onset of symptoms 23,25 .

Delayed treatment-seeking
This is a treatment sought after the recommended time of 24 h onset of malaria symptoms 23,25 .

Waiting time
The time a patient had to wait at registration, consultation, laboratory, and other diagnostic units and at the pharmacy to receive service.If the patient's waiting time is greater or equal to 120 min considered a long waiting time and if the waiting time is less than 120 min it is considered a short waiting time 22 .

Client satisfaction
A subjective measure of whether a patient's expectations about a health encounter were met 22 .

Confidence in healthcare
Confidence in the healthcare system implies an expectation that sufficient and appropriate treatments will be provided if needed 23 .www.nature.com/scientificreports/

Data collection procedure and quality assurance
The questionnaire was initially developed in English by reviewing available literature.The training was given to data collectors and a supervisor.Data were collected by a structured pre-tested questionnaire which was developed by reviewing different peer-reviewed literature 26,27 .The tool consists of sociodemographic characteristics, physical accessibility and environmental factors, behavioral factors, and questions on treatment-seeking delay.
Additionally, knowledge assessment questions on signs/symptoms, transmission, and prevention of malaria were partially adapted from a previously conducted study which contains 12 closed-ended and multiple choice questions where each choice has a score of 1 point 27,28 .

Data processing and analysis
After ensuring completeness and consistency, the data underwent coding and entry into EPI-data v 4.6.0.2, followed by exportation to SPSS 23 statistical software for processing and analysis.Frequency tables and descriptive summaries were employed to depict study variables.Logistic regression analysis assessed the significance of associations between dependent and independent variables.Bivariate and multivariable analyses were conducted to examine the relationship between treatment-seeking delay among malaria patients and selected independent variables.In bivariate logistic regression, variables with a p-value of 0.25 or less were included in the multivariable logistic regression analysis 29 , then p value less than 0.05 was considered a predictor for the delay in treatment-seeking among malaria, and an adjusted odds ratio with 95% CI was considered to see the strength and significance of the association.The adequacy of the final model was checked using the Hosmer and Lemeshow Goodness of fit test.With p-a value was 0.08 30 .Permission was also obtained from the South Gonder District health department and respective health facilities in which the data collection was conducted.Respondents were informed about the objective and purpose of the study and verbal informed consent was obtained from each respondent while permission from parents or guardians was obtained for participants of age less than 18 years also permission was taken from the participants for ages greater and equal to 18 years.Clear information was given to inform respondents about the purpose and procedure of the study, the importance of their participation, and the right to withdraw at any time if they want.Additionally, the respondents were informed about the privacy and confidentiality of the information they provided throughout the study, by maintaining anonymity and interviewing them in a separate room during the interview.All methods were carried out under relevant guidelines and regulations.

Socio-demographic characteristics of participants
A total of 322 study participants (161 cases and 161 controls) were successfully involved in the study.Among the cases (N = 161), 58.4% were male, with 90.1% residing in rural areas.The majority belonged to the Amhara ethnicity (87%) and were married (57.8%).Regarding education, 37.9% were unable to read and write.In terms of occupation, 23.6% were students, and 21.1% were farmers.Monthly income revealed that 72% fell into the lower-income category.Family size varied, with 79.5% having five or more members.Controls (N = 161) exhibited similar trends, with 64.6% being male, 83.2% residing in rural areas, and 81.4% belonging to the Amhara ethnicity.The majority were married (59.6%), and 34.2% had a college education or above (Table 2).

Duration of treatment-seeking and Reasons for delay in treatment-seeking for malaria among cases
Out of the 161 cases, a significant majority, comprising 132 individuals (81.9%), sought medical attention at a health facility within 24 to 48 h of experiencing the initial signs and symptoms.A notable proportion (56.5%) attributed their delayed treatment seeking for malaria to challenges such as limited access to transportation and the elevated cost of medical care associated with seeking treatment at a health facility.

Knowledge about malaria
In this study, 97 (60.2%) of the controls and 71 (44%) of the cases had adequate knowledge about malaria.The majority of the cases (95%) and controls (92.5%) had heard about malaria.Most of the controls 118 (80.3%) and cases 115 (75.2%) had known mosquito bite causes malaria.The majority of the controls (66.4%) and almost half of the cases (54.2%) perceived malaria as a serious and killer disease.Almost all of the controls (95.8%) had listed two or more malaria symptoms.Most of the controls (85.8%) and half of the cases (56.7%) had known how to prevent malaria (Table 3).

Behavioural factors affecting treatment seeking for malaria
The study on behavioral factors influencing malaria treatment-seeking behavior in South Gonder District, Ethiopia (N = 322), reveals distinctive patterns among cases (N = 161) and controls (N = 161).Perception of medication side effects varied, with 60.9% of cases and 39.8% of controls expressing concerns.Health facilities were the primary choice for seeking treatment, particularly for cases (70.8% www.nature.com/scientificreports/28.6% of cases and 23.6% of controls.The decision-maker for seeking treatment predominantly was the patient, representing 62.1% of cases and 69.6% of controls(Table 4).

Physical and environmental factors affecting treatment-seeking for malaria
The study revealed that a significant proportion of controls (78.3%, 126 individuals) and a minority of cases (42.2%, 68 individuals) had easy access to transportation.Most cases (39.1%, 63 individuals) relied on walking for transportation to health facilities.Of the controls, 57.1% (92 individuals) and 36% of cases (58 individuals) reached health facilities within 30 min (Fig. 1).The majority of controls (70.2%, 113 individuals) and a few cases (46%, 74 individuals) were covered by community-based health insurance (CBHI).

Healthcare system-related factors affecting treatment seeking for malaria
The majority of controls (79.5%) and a minority of cases (39.8%) reported a very short waiting period for health services.About one-fourth of controls (24.8%) and nearly half of cases (47.2%) perceived the cost of malaria   healthcare as expensive.Most controls (77%) and cases (83.2%) did not encounter shortages in drugs or laboratory services.Three-fourths of controls (78.9%) and a few cases (41.6%) expressed confidence in the health facility services they received (Table 5).

Determinant factors for delay in treatment seeking for malaria
No Multicollinearity exists among independent variables, as indicated by a Variance Inflation Factor (VIF) of 2.1, well below the threshold of 10.All variables were entered into the bivariable logistic regression model.Sociodemographic variables, such as sex (p = 0.253), age group (p = 0.087), ethnicity (p = 0.171), marital status (p = 0.818), and religion (p = 0.231) were not crudely associated with delay for treatment-seeking.Other variables such as family death (p = 0.577), and taking traditional medicine (p = 0.705) were not crudely associated with delay in treatment-seeking.The bivariable logistic regression knowledge category was crudely associated with delay for treatment-seeking (COR = 1.92(1.23-2.99).All variables with p-value < 0.2 were entered into the multivariable logistic regression model.
In multivariable logistic regression, educational status, malaria drug side effects, provided health education, transportation accessibility, community-based health insurance, and confidence in malaria care were significantly associated with delays in seeking treatment for malaria.www.nature.com/scientificreports/ In this study, Educational status played a crucial role, particularly for those unable to read and write, demonstrating a significantly higher delay compared to other educational categories (AOR = 3.47, p = 0.048).Students also exhibited a distinct trend towards delayed treatment (AOR = 3.34, p = 0.08).Transportation challenges significantly impacted cases, with those facing difficulties almost five times more likely to experience delays (AOR = 4.70, p = 0.02).Lack of community-based health insurance emerged as a significant factor contributing to delay among cases (AOR = 2.50, p = 0.006).Furthermore, cases lacking confidence in malaria treatment had significantly higher odds of delay compared to controls (AOR = 2.14, p = 0.032).
This study revealed that study participants who had no confidence in malaria treatment were 2.14 times more likely to delay seeking treatment for malaria [AOR = 2.14, 95% CI (1.06, 4.29)] with p-value = 0.032 (Table 6).

Discussion
The World Health Organization (WHO) advocates swift access to suitable anti-malarial treatment, preferably within the initial 24 h of fever onset, to prevent progression from uncomplicated to severe malaria 7 .Key findings indicate that unable to read and write, fear of malaria drug side effects, lack of health education, limited transportation, absence of community-based health insurance, and lack of confidence in health facility care contribute to treatment-seeking delays among malaria patients.This study revealed that delay in treatment-seeking among malaria patients had a significant association with educational status, malaria drug side effects, getting health education on malaria, transportation access, CBHI membership, and confidence in health malaria care.The current findings were similar to other studies conducted in North West Ethiopia that showed communitybased health insurance, previous history of malaria infection, and distance were determinants of delay in seeking treatment for malaria 9 .
The current study showed that the educational status of the patient was found to be an important determinant factor for treatment-seeking delay among malaria patients.In this study patients who were unable to read and write were more likely to delay seeking treatment for malaria.This finding was comparable with the study conducted in Myanmar that showed patients who were unable to read and write were more likely to delay seeking treatment for malaria 26 , and a similar finding was reported in a study conducted in the Tigray region 17 .The relationship between educational level and early health-seeking might be because literate people are better able to understand health education messages delivered by different mass media and health professionals.Develop materials that can be understood if the existing health education materials are not comprehended by people with no/poor literacy-then need.
A side-effect of anti-malarial drugs was also found to be a significant factor for delays in treatment-seeking among malaria patients in health facilities.Study participants who experienced side effects of anti-malarial drugs were more likely to delay seeking treatment when they needed malaria treatment.This association might be due to the reason that most of the patients did not visit healthcare early due to fear of its side effects.A consistent finding was reported in other studies conducted in Southern Ethiopia 2.91 times and Southwest Ethiopia 4.96 times more likely to be late for the treatment of malaria care 15,20 .These findings contradict a study conducted in the Northwestern Zone of the Tigray region that showed side effects of anti-malarial drugs had no significant association with delay in treatment-seeking 17 .They may prioritize avoiding potential discomfort from medication over seeking immediate treatment for their illness.
In this study, study participants who had not received any health education regarding malaria were more likely to delay treatment-seeking for malaria.This could be due to those who did not receive health education on malaria disease as a very simple disease and also understood there was no treatment at health facilities due to a lack of knowledge on the treatment.On the other hand, individuals who had received adequate health education on malaria were found to be highly motivated to visit health facilities as early as possible due to sufficient information regarding all of the side effects and their severity.This finding was also concomitant with other study findings from North-western Ethiopia 27 .
The current study showed that study participants, who had no transportation access were more likely to be late in seeking treatment for malaria.This finding was comparable with other studies conducted in Uganda that showed that long distance from the place of residence to public health facilities as a result of transportation access was a notable risk factor for both delayed care seeking and severe malaria 28 and a study from North West Ethiopia was also revealed study participants who traveled for more than 30 min to get to a health facility due to lack of transportation access were more likely to be late in seeking treatment for malaria 9 .The possible explanation for the finding is that study participants who had no transportation access may have faced difficulties in reaching healthcare facilities promptly.This could be due to limited public transportation options, lack of personal vehicles, or living in remote areas with poor road infrastructure.In addition, community-based diagnosis and treatment be considered using community malaria volunteers or community volunteer health volunteers.
This study revealed that members of the CBHI were an important determinant of delayed treatment seeking.Study participants responded that no member of CBHI was likely to delay seeking treatment for malaria.The possible explanation for this could be the shortage of money for a fee for malaria treatment.This finding was in line with a study conducted in Ghana has concluded that those who were members of health insurance schemes were less likely to delay anti-malarial treatment seeking by seeking traditional/herbal medicine and self-medication 31 .Furthermore, a study conducted in Ethiopia has revealed that patients who were not members of community-based health insurance (CBHI) were more likely to delay in seeking treatment when compared to those who were members of CBHI 9 .Confidence in the malaria care provided by health facilities was also another determinant factor of delay in treatment-seeking among malaria patients.This study revealed that study participants who had no confidence in malaria care were more likely to be late to seek treatment.The study's limitations include potential recall bias in participant responses, generalizability constraints to other settings, and reliance on self-reported data, which may introduce subjectivity.

Conclusion
In Summary, this study revealed significant associations between delays in seeking malaria treatment and factors such as educational status (those who were unable to read and write), malaria drug side effects, health education on malaria, transportation access, CBHI membership, and confidence in health malaria care.It is recommended that targeted interventions and awareness campaigns be implemented to address these determinants, promoting prompt and effective malaria treatment-seeking behavior in the studied population (Supplementary Information).

Figure 1 .
Figure 1.Physical and environmental factors affecting treatment-seeking for malaria among study participants in public health facilities of South Gonder District, 2022(n = 322).

Table 1 .
Variables used to calculate the largest possible sample size.
Vol:.(1234567890) Scientific Reports | (2024) 14:6648 | https://doi.org/10.1038/s41598-024-56413-7 Ethical approval was obtained from the Institutional Review Board of Wollo University, College of Medicine and Health Science with the reference number of Ref no: CMHS/85/13/2022.Following the approval, an Official letter of cooperation was written to concerned bodies by the School of Public Health of Wollo University.

Table 2 .
Socio-demographic characteristics of study participants in public health facilities of South Gonder District, Ethiopia, 2022(n = 322).

Table 3 .
Knowledge about malaria among study participants in public health facilities of South Gonder District, 2022(n = 322).

Table 5 .
Health care system related factors affecting treatment seeking for malaria among study participants in public health facilities of South Gonder District, Ethiopia, 2022 (n = 322).

Table 6 .
Multivariable logistic regression for the determinant of delay in treatment seeking for malaria among study participants in public health facilities of South Gonder District, Ethiopia, 2022(n = 322).*Significantly associated variables.