Since Nature Structural and Molecular Biology was started 30 years ago, our understanding of transcription and mRNA processing has been revolutionized through structural and mechanistic studies. Here, we present our personal views of the advances in understanding the production of mature eukaryotic mRNAs over the past decade.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Kühlbrandt, W. Science 343, 1443–1444 (2014).
Osman, S. & Cramer, P. Annu. Rev. Cell Dev. Biol. 36, 1–34 (2020).
Aibara, S., Schilbach, S. & Cramer, P. Nature 594, 124–128 (2021).
Chen, X. et al. Science 378, 62–68 (2022).
Ehara, H. et al. Science 363, 744–747 (2019).
Nagai, K., Oubridge, C., Jessen, T. H., Li, J. & Evans, P. R. Nature 348, 515–520 (1990).
Pomeranz Krummel, D. A., Oubridge, C., Leung, A. K., Li, J. & Nagai, K. Nature 458, 475–480 (2009).
Nguyen, T. H. et al. Nature 523, 47–52 (2015).
Wilkinson, M. E., Charenton, C. & Nagai, K. Annu. Rev. Biochem. 89, 359–388 (2020).
Casañal, A. et al. Science 358, 1056–1059 (2017).
Clerici, M., Faini, M., Muckenfuss, L. M., Aebersold, R. & Jinek, M. Nat. Struct. Mol. Biol. 25, 135–138 (2018).
Zhang, Y., Sun, Y., Shi, Y., Walz, T. & Tong, L. Mol. Cell 77, 800–809.e6 (2020).
Jumper, J. et al. Nature 596, 583–589 (2021).
Krishna, R. et al. Science, eadl2528 (2024).
Zhang, S. et al. Science 371, 305–309 (2021).
Acknowledgements
Work in our laboratories is funded by the Medical Research Council, as part of United Kingdom Research and Innovation, MRC file reference numbers MC_U105192715 (L.A.P.) and MC_UP_1201/30 (S.Z.), and the Wellcome Trust, grant 225217/Z/22/Z (L.A.P.).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Passmore, L.A., Zhang, S. Mechanisms of transcription and RNA processing. Nat Struct Mol Biol 31, 730–731 (2024). https://doi.org/10.1038/s41594-024-01312-8
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41594-024-01312-8
