A growing body of evidence suggests that cotranslational folding occurs from bacteria to mammalian cells, in particular for multi-domain proteins. In the assembly of yeast proteasomes, the initial interaction of Rpt1 and Rpt2 subunits has been found to take place on the translating ribosomes, coordinated by elongation pausing and involving the formation of Not1-containing compartments.
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References
Sosnick, T. R. & Barrick, D. Curr. Opin. Struct. Biol. 21, 12–24 (2011).
Kramer, G., Boehringer, D., Ban, N. & Bukau, B. Nat. Struct. Mol. Biol. 16, 589–597 (2009).
Kramer, G., Shiber, A. & Bukau, B. Annu. Rev. Biochem. https://doi.org/10.1146/annurev-biochem-013118-111717 (2018).
Balchin, D., Hayer-Hartl, M. & Hartl, F. U. Science 353, aac4354 (2016).
Natan, E., Wells, J. N., Teichmann, S. A. & Marsh, J. A. Curr. Opin. Struct. Biol. 42, 90–97 (2017).
Ingolia, N. T., Ghaemmaghami, S., Newman, J. R. & Weissman, J. S. Science 324, 218–223 (2009).
Oh, E. et al. Cell 147, 1295–1308 (2011).
Han, Y. et al. Proc. Natl Acad. Sci. USA 109, 12467–12472 (2012).
Shieh, Y. W. et al. Science 350, 678–680 (2015).
Shiber, A. et al. Nature 561, 268–272 (2018).
Bard, J. A. M. et al. Annu. Rev. Biochem. 87, 697–724 (2018).
Collins, G. A. & Goldberg, A. L. Cell 169, 792–806 (2017).
Panasenko, O.O. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-018-0179-5 (2019).
Doerfel, L. K. et al. Science 339, 85–88 (2013).
Gutierrez, E. et al. Mol. Cell 51, 35–45 (2013).
Zhang, G., Hubalewska, M. & Ignatova, Z. Nat. Struct. Mol. Biol. 16, 274–280 (2009).
Inobe, T. & Genmei, R. PLoS One 10, e0134056 (2015).
Panasenko, O. O. & Collart, M. A. Mol. Cell. Biol. 31, 1610–1623 (2011).
Collart, M. A. Wiley Interdiscip. Rev. RNA 7, 438–454 (2016).
Yamaguchi, T. et al. Sci. Signal. 11, eaan3638 (2018).
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Liu, XM., Qian, SB. Assembly en route. Nat Struct Mol Biol 26, 89–91 (2019). https://doi.org/10.1038/s41594-019-0185-2
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DOI: https://doi.org/10.1038/s41594-019-0185-2
