Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News Feature
  • Published:

Autoimmune disease is the next frontier for CAR T cell therapy

CAR T cell therapy has transformed the treatment of B cell cancers and is now being pursued by biotech companies for conditions as varied as systemic lupus erythematosus, diabetes and organ rejection.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Targeted killing by a CAR T cell.

References

  1. Kansal, R. et al. Sci. Transl. Med. 11, eaav1648 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Mougiakakos, D. et al. New Engl. J. Med. 385, 567–569 (2021).

    Article  PubMed  Google Scholar 

  3. Mackensen, A. et al. Nat. Med. 28, 2124–2132 (2022).

    Article  CAS  PubMed  Google Scholar 

  4. Klatzmann, D. et al. Science 225, 59–63 (1984).

    Article  CAS  PubMed  Google Scholar 

  5. Harrison, A. J., Du, X., von Scheidt, B., Kershaw, M. H. & Slaney, C. L. Immunother. Adv. 1, ltab016 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Arnold, C. Autoimmune disease is the next frontier for CAR T cell therapy. Nat Med 30, 6–9 (2024). https://doi.org/10.1038/s41591-023-02716-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41591-023-02716-7

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing