A yeast strain engineered to regulate levels of pathogenic metabolites in the gut provides protection against colitis in mouse models.
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References
Nagler, C. R. J. Exp. Med. 217, e20191642 (2020).
Honda, K. & Littman, D. R. Nature 535, 75–84 (2016).
Fischbach, M. A. Cell 174, 785–790 (2018).
Jimenez, M., Langer, R. & Traverso, G. J. Exp. Med. 216, 1005–1009 (2019).
Scott, B. M. et al. Nat. Med. https://doi.org/10.1038/s41591-021-01390-x (2021).
Xavier, R. J. & Podolsky, D. K. Nature 448, 427–434 (2007).
Sonnenburg, J. L. & Sonnenburg, E. D. Science 366, eaaw9255 (2019).
Neurath, M. F. Nat. Immunol. 20, 970–979 (2019).
D’Amico, F., Peyrin-Biroulet, L., Danese, S. & Fiorino, G. Curr. Opin. Pharmacol. 55, 141–150 (2020).
Mimee, M., Citorik, R. J. & Lu, T. K. Adv. Drug Deliv. Rev. 105, 44–54 (2016).
Steidler, L. et al. Science 289, 1352–1355 (2000).
Isabella, V. M. et al. Nat. Biotechnol. 36, 857–864 (2018).
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C.R.N. is the president and co-founder of ClostraBio.
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Mimee, M., Nagler, C.R. Engineered yeast tune down gut inflammation. Nat Med 27, 1150–1151 (2021). https://doi.org/10.1038/s41591-021-01420-8
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DOI: https://doi.org/10.1038/s41591-021-01420-8
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