Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

BIOENGINEERING

Engineered yeast tune down gut inflammation

A yeast strain engineered to regulate levels of pathogenic metabolites in the gut provides protection against colitis in mouse models.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Yeast engineered to regulate eATP levels in the inflamed gut.

References

  1. Nagler, C. R. J. Exp. Med. 217, e20191642 (2020).

    Article  Google Scholar 

  2. Honda, K. & Littman, D. R. Nature 535, 75–84 (2016).

    Article  CAS  Google Scholar 

  3. Fischbach, M. A. Cell 174, 785–790 (2018).

    Article  CAS  Google Scholar 

  4. Jimenez, M., Langer, R. & Traverso, G. J. Exp. Med. 216, 1005–1009 (2019).

    Article  CAS  Google Scholar 

  5. Scott, B. M. et al. Nat. Med. https://doi.org/10.1038/s41591-021-01390-x (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Xavier, R. J. & Podolsky, D. K. Nature 448, 427–434 (2007).

    Article  CAS  Google Scholar 

  7. Sonnenburg, J. L. & Sonnenburg, E. D. Science 366, eaaw9255 (2019).

    Article  CAS  Google Scholar 

  8. Neurath, M. F. Nat. Immunol. 20, 970–979 (2019).

    Article  CAS  Google Scholar 

  9. D’Amico, F., Peyrin-Biroulet, L., Danese, S. & Fiorino, G. Curr. Opin. Pharmacol. 55, 141–150 (2020).

    Article  Google Scholar 

  10. Mimee, M., Citorik, R. J. & Lu, T. K. Adv. Drug Deliv. Rev. 105, 44–54 (2016).

    Article  CAS  Google Scholar 

  11. Steidler, L. et al. Science 289, 1352–1355 (2000).

    Article  CAS  Google Scholar 

  12. Isabella, V. M. et al. Nat. Biotechnol. 36, 857–864 (2018).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Cathryn R. Nagler.

Ethics declarations

Competing interests

C.R.N. is the president and co-founder of ClostraBio.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mimee, M., Nagler, C.R. Engineered yeast tune down gut inflammation. Nat Med 27, 1150–1151 (2021). https://doi.org/10.1038/s41591-021-01420-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41591-021-01420-8

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing