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Functional T cell tolerance by peripheral tissue-based checkpoint control

Nature Immunology volume 24, pages 1224–1225 (2023)Cite this article

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Delineation of the steps that lead to immune-related adverse effects indicates that checkpoint-mediated suppression of autoreactive T cells occurs within peripheral target tissues rather than at the point of lymph node activation.

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Fig. 1: Peripheral functional T cell tolerance by the tissue-localized action of checkpoint receptors.

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Acknowledgements

L.K.M. is a senior medical research fellow supported by the Sylvia and Charles Viertel Charitable Foundation.

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  1. Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria, Australia

    Francis R. Carbone & Laura K. Mackay

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  1. Francis R. Carbone
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  2. Laura K. Mackay
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Correspondence to Francis R. Carbone or Laura K. Mackay.

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The authors declare no competing interests.

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Carbone, F.R., Mackay, L.K. Functional T cell tolerance by peripheral tissue-based checkpoint control. Nat Immunol 24, 1224–1225 (2023). https://doi.org/10.1038/s41590-023-01574-2

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