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Dendritic cells

tDCs — a distinct subset with dual functional and developmental roles

Confusion exists as to whether transitional dendritic cells are a bone fide subset or just a transitional state, as the name indicates. New data are complicating matters further by showing some interesting heterogeneity in these cells.

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Fig. 1: tDC function during steady state and infection.

References

  1. See, P. et al. Science 356, eaag3009 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Villani, A. C. et al. Science 356, eaah4573 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  3. Leylek, R. et al. Cell Rep. 29, 3736–3750 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Sulczewski, F. B. et al. Nat. Immunol. https://doi.org/10.1038/s41590-023-01545-7 (2023).

    Article  PubMed  Google Scholar 

  5. Naik, S. H. Mol. Immunol. 124, 190–197 (2020).

    Article  CAS  PubMed  Google Scholar 

  6. Schlitzer, A. et al. Nat. Immunol. 16, 718–728 (2015).

    Article  CAS  PubMed  Google Scholar 

  7. Grajales-Reyes, G. E. et al. Nat. Immunol. 16, 708–717 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Coillard, A. & Segura, E. Front Immunol. 10, 1907 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Calame, K. L. Nat. Immunol. 2, 1103–1108 (2001).

    Article  CAS  PubMed  Google Scholar 

  10. Rodrigues, P. F. et al. Sci. Immunol. 8, eadd4132 (2023).

    Article  CAS  PubMed  Google Scholar 

Download references

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Correspondence to Shalin H. Naik.

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Audiger, C., Tomei, S. & Naik, S.H. tDCs — a distinct subset with dual functional and developmental roles. Nat Immunol 24, 1222–1223 (2023). https://doi.org/10.1038/s41590-023-01565-3

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