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Adaptive immunity

Bound to be perfect: Lck and T cell co-receptors

Nature Immunology volume 24, pages 5–7 (2023)Cite this article

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Interactions between the T cell co-receptors CD4 or CD8 and the kinase Lck safeguard T cell activation by low-affinity ligands. Meanwhile, ‘free’ Lck — which cannot bind co-receptors — elicits efficient anti-viral and anti-tumor responses by CD8+ T cells in vivo.

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Fig. 1: Interactions between co-receptors and the protein tyrosine kinase Lck are differentially required by CD4+ and CD8+ T cells, and are largely dispensable for efficient anti-viral and anti-tumor responses.

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Authors and Affiliations

  1. Center of Disease Model and Immunology, Hunan Academy of Chinese Medicine, Changsha, China

    Yinming Liang

  2. School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, China

    Yinming Liang

  3. Institute of Immunology, Third Military Medical University, Chongqing, China

    Lilin Ye

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  1. Yinming Liang
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  2. Lilin Ye
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Correspondence to Yinming Liang or Lilin Ye.

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Liang, Y., Ye, L. Bound to be perfect: Lck and T cell co-receptors. Nat Immunol 24, 5–7 (2023). https://doi.org/10.1038/s41590-022-01392-y

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