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INHIBITORY MOLECULE REGULATION

Two CTLA-4 ligands, separate pHates

Nature Immunology volume 23, pages 1297–1299 (2022)Cite this article

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The inhibitory checkpoint molecule CTLA-4 is essential for regulatory T cell function. A new study highlights the differential manner in which CTLA-4 binds CD80 and CD86, which determines its cellular fate and orchestrates immune tolerance regulation.

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Fig. 1: The molecular fates of transendocytosed CTLA-4 are determined in the endolysosomal network.

References

  1. Baumeister, S. H. et al. Annu. Rev. Immunol. 34, 539–573 (2016).

    Article  CAS  Google Scholar 

  2. Wing, K. et al. Science. 322, 271–275 (2008).

    Article  CAS  Google Scholar 

  3. Kennedy, A. et al. Nat. Immunol. 23, https://doi.org/10.1038/s41590-022-01289-w (2022).

  4. Rowshanravan, B. et al. Blood 131, 58–67 (2018).

    Article  CAS  Google Scholar 

  5. Lo, B. et al. Blood 128, 1037–1042 (2016).

    Article  CAS  Google Scholar 

  6. Sugiura, D. et al. Science 364, 558–566 (2019).

    Article  CAS  Google Scholar 

  7. Tekguc, M. et al. Proc. Natl Acad. Sci. USA 118, e2023739118 (2021).

    Article  CAS  Google Scholar 

  8. Vijayakrishnan, L. et al. Immunity 20, 563–575 (2004).

    Article  CAS  Google Scholar 

  9. Igawa, T. et al. Nat. Biotechnol. 28, 1203–1207 (2010).

    Article  CAS  Google Scholar 

  10. Zhang, Y. et al. Cell Res. 29, 609–627 (2019).

    Article  CAS  Google Scholar 

  11. Lee, P. S. et al. MAbs 14, 2024642 (2022).

    Article  Google Scholar 

  12. Li, T. et al. J. Immunother. Cancer 9, A998 (2021).

Download references

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Authors and Affiliations

  1. Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA

    Preston A. Humphries & Wan-Lin Lo

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  1. Preston A. Humphries
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  2. Wan-Lin Lo
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Correspondence to Wan-Lin Lo.

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The authors declare no competing interests.

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Humphries, P.A., Lo, WL. Two CTLA-4 ligands, separate pHates. Nat Immunol 23, 1297–1299 (2022). https://doi.org/10.1038/s41590-022-01296-x

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