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New functions for basophils identified in kidney fibrosis

Nature Immunology volume 23, pages 824–825 (2022)Cite this article

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Basophils are type 2 immune response cells, but they have also been associated with fibrosis. New data indicate that proximal tubule cells exert profibrotic effects by recruiting IL-6-producing basophils into the kidneys.

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Fig. 1: The function of PT, immune and stromal cells in kidney fibrosis.

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA

    Haikuo Li & Benjamin D. Humphreys

  2. Department of Developmental Biology, Washington University in St. Louis, St. Louis, MO, USA

    Benjamin D. Humphreys

Authors
  1. Haikuo Li
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  2. Benjamin D. Humphreys
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Correspondence to Benjamin D. Humphreys.

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Competing interests

B.D.H. is a consultant for Janssen Research & Development, Pfizer, and Chinook Therapeutics; holds equity in Chinook Therapeutics; and previously held grant funding from Chinook Therapeutics and Janssen Research & Development.

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Li, H., Humphreys, B.D. New functions for basophils identified in kidney fibrosis. Nat Immunol 23, 824–825 (2022). https://doi.org/10.1038/s41590-022-01221-2

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