Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Vaccine development

Flipping hemagglutinin on its head

Antigen reorientation via oligoD, a label-free, alum-based technique, guides immunofocused, broadly reactive antibody responses.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: HA antigen configurations bound to alum adjuvant via oligoD.

References

  1. Ward, A. B. & Wilson, I. A. Curr. Opin. Immunol. 65, 50–56 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Krammer, F. Nat. Rev. Immunol. 19, 383–397 (2019).

    Article  CAS  PubMed  Google Scholar 

  3. Bernstein, D. I. et al. Lancet Infect. Dis. 20, 80–91 (2020).

    Article  CAS  PubMed  Google Scholar 

  4. Arevalo, C. P. et al. Science 378, 899–904 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Moin, S. M. et al. Immunity 55, 2405–2418.e7 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Xu, D. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01529-6 (2024).

    Article  PubMed  Google Scholar 

  7. Brewer, J. M. Immunol. Lett. 102, 10–15 (2006).

    Article  CAS  PubMed  Google Scholar 

  8. Verma, S. K. et al. Front. Immunol. 14, 1043109 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Moyer, T. J. et al. Nat. Med. 26, 430–440 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Turner, H. L. et al. STAR Protoc. 4, 102476 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to James A. Ferguson.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ferguson, J.A., Han, J. & Ward, A.B. Flipping hemagglutinin on its head. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01545-0

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41589-024-01545-0

Search

Quick links

Nature Briefing Microbiology

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing: Microbiology