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Metabolism

METTL3 restrains autoimmunity in β-cells

Nature Cell Biology volume 26, pages 321–322 (2024)Cite this article

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Activation of innate immunity has been linked to the progression of type 1 diabetes. A study now shows that overexpression of METTL3, a writer protein of the m6A machinery that modifies mRNA, restrains interferon-stimulated genes when expressed in pancreatic β-cells, identifying it as a promising therapeutic target.

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Fig. 1: Possible effects of METTL3 overexpression in β-cells and T cells.

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Authors and Affiliations

  1. Immunology and Diabetes Unit, St Vincent’s Institute, Fitzroy, Melbourne, Victoria, Australia

    Balasubramanian Krishnamurthy & Helen E. Thomas

  2. Department of Medicine, St Vincent’s Hospital, University of Melbourne, Fitzroy, Melbourne, Victoria, Australia

    Balasubramanian Krishnamurthy & Helen E. Thomas

Authors
  1. Balasubramanian Krishnamurthy
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  2. Helen E. Thomas
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Correspondence to Helen E. Thomas.

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Krishnamurthy, B., Thomas, H.E. METTL3 restrains autoimmunity in β-cells. Nat Cell Biol 26, 321–322 (2024). https://doi.org/10.1038/s41556-024-01352-8

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