Cell–cell adhesions are inevitably exposed to mechanical forces. A landmark paper by Yonemura et al. identified how tension alters molecular function of the cadherin adhesion apparatus. Its legacy lies in the many on-going efforts to understand how mechanical force is used in cell–cell communication.
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Mann, Z., Yap, A.S. Talking with force at cell–cell adhesions. Nat Cell Biol 26, 26–28 (2024). https://doi.org/10.1038/s41556-023-01263-0
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DOI: https://doi.org/10.1038/s41556-023-01263-0