Programmed death ligand-1 (PD-L1) is well known for its role as an immune checkpoint regulator, but little is known about its function in other cellular processes. A study now shows that in tumour cells PD-L1 mediates pyroptosis, an inflammatory form of cell death, by activating the expression of Gasdermine C, ultimately leading to tumour necrosis.
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Blasco, M.T., Gomis, R.R. PD-L1 controls cancer pyroptosis. Nat Cell Biol 22, 1157–1159 (2020). https://doi.org/10.1038/s41556-020-00582-w
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DOI: https://doi.org/10.1038/s41556-020-00582-w
