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Post-intervention Adherence to the New Nordic Renal Diet among patients with chronic kidney disease, stages 3 and 4

European Journal of Clinical Nutrition (2024)Cite this article

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Abstract

The New Nordic Renal Diet (NNRD) is a meal pattern reduced in phosphorus, protein, and sodium for patients with moderate chronic kidney disease. The NNRD showed improvements in metabolic, and physiological outcomes after 26-weeks intervention. In the original study, participants were randomized to NNRD (n = 30), or control (habitual diet) (n = 30). The aim of this study was to explore adherence to the NNRD 3 months after cessation of intervention (follow-up). Fifty-seven participants completed the follow-up visit, which consisted of fasting blood samples and 24 h urine samples. At follow-up, there was no longer a significant reduction in 24 h urine phosphorus excretion in the NNRD group. From intervention to follow-up, 24 h urine phosphorus increased by 63 mg in the NNRD group, vs. −24.1 mg in the control group, between-group difference 87.1 mg (−10.1, 184.3, p = 0.08). Our findings show that more active intervention is needed to support adherence and maintain beneficial effects of the NNRD.

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Fig. 1: Absolut change in 24 h urine phosphorus excretion from baseline to followup.

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Data availability

Data described in the manuscript, code book, and analytic code will be made available upon request.

References

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Funding

This project has received financial funding from Augustinus Foundation (N/A), Gangsted Foundation (N/A), Helen and Ejnar Bjørnow Foundation (N/A), the Capital Region of Denmark’s Research Foundation (N/A) and the Danish Kidney Association (N/A).

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Authors and Affiliations

  1. Department of Nephrology, Copenhagen University Hospital – Rigshospitalet, Copenhagen, Denmark

    Nikita Misella Hansen, Anne-Lise Kamper, Marianne Rix, Bo Feldt-Rasmussen & Louise Salomo

  2. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

    Nikita Misella Hansen & Bo Feldt-Rasmussen

  3. Department of Biomedicine, Aarhus University, Aarhus, Denmark

    Mads Vaarby Sørensen & Peder Berg

  4. Department of Obesity and Nutritional Sciences, Novo Nordisk Foundation, Hellerup, Denmark

    Arne Astrup

Authors
  1. Nikita Misella Hansen
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  2. Anne-Lise Kamper
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  3. Marianne Rix
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  4. Bo Feldt-Rasmussen
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  5. Mads Vaarby Sørensen
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  6. Peder Berg
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  7. Arne Astrup
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  8. Louise Salomo
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Contributions

NMH, LS, AA, MR, and ALK designed the study. NMH conducted the research and collected all data, and LS supervised the study including medical safety aspects. PB performed the statistical analyses. NMH, AA, LS, PB, ALK, MR, BFR, and MVS analyzed the data and interpreted the data. NMH and AA wrote the paper. NMH and AA had primary responsibility for the final content. All authors have read and approved the manuscript.

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Correspondence to Nikita Misella Hansen.

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Competing interests

The authors declare no competing interests.

Ethical

This study was conducted in accordance with the standards of the Declaration of Helsinki and was approved by the Scientific Ethical Committee of the Capital Region of Denmark (H-20026376), as well as the Danish Data Protection Agency. All participants handed in their written consent prior to inclusion in the study.

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Hansen, N.M., Kamper, AL., Rix, M. et al. Post-intervention Adherence to the New Nordic Renal Diet among patients with chronic kidney disease, stages 3 and 4. Eur J Clin Nutr (2024). https://doi.org/10.1038/s41430-024-01413-z

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  • DOI: https://doi.org/10.1038/s41430-024-01413-z

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