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New naphthyl derivatives from Aspergillus californicus

The Journal of Antibiotics volume 74, pages 111–114 (2021)Cite this article

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Abstract

Two new naphthyl-products calinaphthyltriol A (1) and calinaphthalenone A (2) were isolated from Aspergillus californicus IBT 16748 together with one known compound ophiobolin X (3). Their structures were elucidated by extensive spectroscopic analyses. The absolute configuration of 2 was solved by comparing its optical rotation with data for the known compounds 4, 5, and 6 as well as theoretical calculations. The antibacterial and cytotoxic activities of 1 and 3 were evaluated. Both compounds did not show antibacterial activity (MIC > 96 µg·ml−1) against a few selected clinically relevant Gram positive and Gram negative bacterial strains. However, they showed moderate cytotoxicity against HL-60 cell line with IC50 values of 18 and 24 µg·ml−1, respectively.

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Acknowledgements

The authors thank Dr. Kasper Enemark-Rasmussen and Associate Professor René Wugt Larsen from Department of Chemistry at the Technical University of Denmark for acquiring NMR and IR data, respectively. YG is financially supported by the China Scholarship Council and Department of Biotechnology and Biomedicine at the Technical University of Denmark.

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Authors and Affiliations

  1. Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, Building 221, DK-2800, Kgs. Lyngby, Denmark

    Yaojie Guo & Thomas O. Larsen

  2. Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123, Brescia, Italy

    Simone Ghidinelli

  3. Fundación MEDINA, Parque Tecnológico de Ciencias de la Salud, Avda. del Conocimiento 34, 18016, Armilla, Granada, Spain

    Mercedes de la Cruz, Thomas A. Mackenzie, Maria C. Ramos, Pilar Sánchez, Francisca Vicente & Olga Genilloud

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  1. Yaojie Guo
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  4. Thomas A. Mackenzie
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Correspondence to Thomas O. Larsen.

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Guo, Y., Ghidinelli, S., de la Cruz, M. et al. New naphthyl derivatives from Aspergillus californicus. J Antibiot 74, 111–114 (2021). https://doi.org/10.1038/s41429-020-00372-4

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