Retraction to: Cell Death and Disease (2017) 8:e2578–e2578; https://doi.org/10.1038/cddis.2016.403, published online 02 February 2017
The Editors are retracting this article because of concerns with a number of figures. An investigation by the University of Milan confirmed that:
-
The same vinculin bands for lanes 2–11 in Fig. 3b are used for vinculin lanes 1–10 in Fig. 5b, but the lysates are claimed to derive from different cell types.
-
Vinvulin bands in Fig. 3d had been used to represent vinculin in a different experiment published in [1].
-
In Fig. 4a, vinculin band in lane 2 is the same as vinculin band lane 2 in Fig. 4b; in Fig. 4a, the vinculin band in lane 7 is the same as that in lane 9 but it has been stretched horizontally; in Fig. 4b, vinculin bands in lanes 4 and 6 are the same.
-
In Fig. 5b, vinculin bands in lanes 2, 3, & 4 are the same as those in lanes 8, 9, & 10.
-
In Fig. 4b, vinculin bands are the same as those that appear representing different experiments in other publications namely [2,3,4].
-
The vinculin bands in Fig. 5b had previously been used to represent those of a different experiment published in [5].
-
Vinculin bands in Fig. 6b were used to represent vinculin in a different experiment published in Fig. 9b in [6].
The Editors therefore no longer have confidence in the data.
Maria Alfonsina Desiderio disagrees with this retraction. Paola Bendinelli, Paola Maroni and Emanuela Matteucci have not responded to any correspondence from the editor/publisher about this retraction.
References
Matteucci E, Bendinelli P, Desiderio MA. Nuclear localization of active HGF receptor Met in aggressive MDA-MB231 breast carcinoma cells. Carcinogenesis. 2009;30:937–45. https://doi.org/10.1093/carcin/bgp080
Bendinelli P, Matteucci E, Maroni P, Desiderio MA. NF-κB activation, dependent on acetylation/deacetylation, contributes to HIF-1 activity and migration of bone metastatic breast carcinoma cells. Mol Cancer Res. 2009;7:1328–41. https://doi.org/10.1158/1541-7786.MCR-08-0548
Maroni P, Bendinelli P, Matteucci E, Locatelli A, Nakamura T, Scita G. et al. Osteolytic bone metastasis is hampered by impinging on the interplay among autophagy, anoikis and ossification. Cell Death Dis. 2014;5:e1005. https://doi.org/10.1038/cddis.2013.465.
Bendinelli P, Maroni P, Matteucci E, Desiderio MA. RETRACTED ARTICLE: HGF and TGFβ1 differently influenced Wwox regulatory function on Twist program for mesenchymal-epithelial transition in bone metastatic versus parental breast carcinoma cells. Mol Cancer. 2015;14:112. https://doi.org/10.1186/s12943-015-0389-y.
Ridolfi E, Matteucci E, Maroni P, Desiderio MA. Inhibitory effect of HGF on invasiveness of aggressive MDA-MB231 breast carcinoma cells, and role of HDACs. Br J Cancer. 2008;99:1623–34. https://doi.org/10.1038/sj.bjc.6604726.
Maroni P, Matteucci E, Luzzati A, Perrucchini G, Bendinelli P, Desiderio MA. Nuclear co-localization and functional interaction of COX-2 and HIF-1α characterize bone metastasis of human breast carcinoma. Breast Cancer Res Treat. 2011;129:433–50. https://doi.org/10.1007/s10549-010-1240-1.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Bendinelli, P., Maroni, P., Matteucci, E. et al. Retraction Note to: Epigenetic regulation of HGF/Met receptor axis is critical for the outgrowth of bone metastasis from breast carcinoma. Cell Death Dis 13, 542 (2022). https://doi.org/10.1038/s41419-022-04992-6
Published:
DOI: https://doi.org/10.1038/s41419-022-04992-6