Abstract
Peripheral T-cell lymphomas (PTCL) other than anaplastic large-cell lymphoma are rare in children, and the role of hematopoietic stem cell transplantation (HSCT) has not been clarified yet. In a retrospective analysis of registry-data of the European Society for Blood and Marrow Transplantation we analyzed 55 patients aged < 18 years who received allogeneic (N = 46) or autologous (N = 9) HSCT for PTCL. Median age at HSCT was 13.9 years; 33 patients (60%) were in first remission, and 6 (19%) in progression at HSCT. Conditioning was myeloablative in 87% of the allogeneic HSCTs and in 27 (58.7%) based on total body irradiation. After allogeneic HSCT the 5-year overall- and progression-free survival was 58.9% (95% CI 42.7–71.9) and 52.6% (95% CI 36.8–66.1), respectively. 5-year relapse incidence was 27.6% (95% CI 15.1–41.6), the non-relapse mortality rate was 19.8% (95% CI 9.7–32.6). Five of the six patients with progression at HSCT died. Seven of nine patients after autologous HSCT were alive and disease-free at last follow-up. Our data suggest a role of allogeneic HSCT in consolidation-treatment of patients with high-risk disease, who reach at least partial remission after primary- or relapse-therapy, whereas patients with therapy-refractory or progressive disease prior to transplantation do not profit from HSCT.
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Introduction
Peripheral T-cell lymphoma (PTCL) is a rare and heterogenous group of Non-Hodgkin-Lymphoma (NHL) [1], accounting for 0.9–1.8% of childhood NHL [2,3,4]. Distribution of PTCL-subtypes in pediatrics differs from reports in adults [5]. In children, most common is PTCL non-otherwise specified (PTCL-NOS), followed by extranodal natural-killer/T-cell lymphoma (ENKTCL)-nasal type, hepatosplenic T-cell lymphoma (HSTCL), subcutaneous-panniculitis-like T-cell lymphoma (SPTCL), and angioimmunoblastic T-cell lymphoma (AITL). Because of the low incidence there is limited data regarding the optimal treatment for pediatric PTCL. Recent reports show major differences in the gene expression profile and somatic mutations between adult and pediatric PTCL indicating different biology of the diseases [5, 6]. Accordingly, children with PTCL might benefit from different treatment strategies than adults. The 5-years overall survival (OS) rates of approximately 55% are inferior compared to other NHL-entities in children, and highly subgroup-dependent, ranging from 83% for SPTCL to 16% for HSTCL [2,3,4, 7,8,9,10]. Patients presenting with advanced-stage disease show worse outcome. In addition, patients with preexisting conditions such as primary or secondary immunodeficiency (up to 25% of children with PTCL) have a dismal outcome with OS around 30% [7]. The role of autologous/allogeneic hematopoietic stem-cell transplantation (HSCT) in the treatment of pediatric PTCL is still unclear. Therefore, we performed a retrospective analysis of HSCT-outcomes for children with PTCL based on registry data of the European Society for Blood and Marrow Transplantation (EBMT).
Patients and methods
Patients aged < 18 years at first transplantation for PTCL according to the WHO-classification [1], except of ALK-positive and negative anaplastic large-T-cell lymphoma (ALCL), transplanted between 1995 and 2015, who received allogeneic HSCT (allo-HSCT) or autologous HSCT (ASCT) were included in the analysis.
We reviewed the data of all patients fulfilling the inclusion criteria from centers reporting to the database of the EBMT. In addition, a specifically designed questionnaire was sent to all participating centers for information that was not available from the database (see supplementary material). Analyses were conducted in accordance with the Declaration of Helsinki, after signed informed consent of the legal guardians had been obtained.
Statistic methods
Patients, donors and HSCT characteristics were described using medians and interquartile ranges (IQR) for quantitative variables and percentages for categorical variables.
The study primary endpoints were OS and progression-free survival (PFS). Secondary endpoints were relapse incidence (RI), non-relapse mortality (NRM). OS was defined as the time from transplantation to death, regardless of cause. PFS was calculated as time from transplant to relapse, progression or death from any other cause. Relapse was defined as progressive lymphoma after HSCT or lymphoma recurrence after complete remission. NRM was defined as death without relapse or progression.
OS and PFS were calculated using the Kaplan-Meier estimates. Cumulative incidence functions were used to estimate the endpoints for RI, NRM, acute/chronic GVHD, and neutrophil engraftment to accommodate for competing risks. The follow-up period for patients was calculated using reverse Kaplan-Meier estimates.
Statistical analyses were performed with R 4.0.2 [R Core Team (2017). R: A language and environment for statistical computing; R Foundation for Statistical Computing, Vienna, Austria] software packages.
Results
Out of 125 patients < 18 years diagnosed with PTCL who were registered to the EBMT-database and transplanted between 1995 and 2015, we obtained sufficient data about HSCT in 55 patients (Fig. 1). Thirty-eight patients had PTCL-NOS, 7 HSTCL, 4 AITL, 3 ENKTCL, 2 SPTCL, and 1 systemic EBV-positive T-cell lymphoma of childhood. Median age at HSCT was 13.9 years (range: 2.5–17.9) [IQR 9.73–16.25]; 36 (65.4%) of the patients were male. Of all analyzed patients 4 suffered from a known cancer-predisposing syndrome/primary immunodeficiency, and 4 from secondary immunodeficiency. 42 (91.3%) out of 46 patients with available staging data presented with advanced-stage disease (stage III/IV), and 23 (62.2%) with B-symptoms at first diagnosis. Patient characteristics are depicted in Table 1.
Treatment prior to HSCT
In primary treatment there was an equal distribution between lymphoblastic lymphoma/T-cell-type- and pulse-B-NHL/ALCL-like chemotherapy (12 versus 10 patients, respectively), as previously described [11,12,13,14,15,16,17]. 7 patients received miscellaneous treatment, however there was missing information about primary treatment in 26 patients. Radiotherapy was not part of the primary treatment in most of the patients (97.9%). 26 patients (49.1%) achieved complete remission (CR) after the primary treatment, 12 (22.6%) showed partial response (PR), 6 (11.3%) stable disease (SD), and 9 (17%) progressive/refractory disease (PD), respectively. Information about status after primary treatment was missing in two patients. 28 (53.9%) patients relapsed after the first-line treatment. Before HSCT, 30 patients (55.6%) showed at least one relapse. Of those, 26 (57.8%) proceeded eventually to allo-HSCT, and 4 (44.4%) to ASCT. 24 patients were without relapse prior to HSCT, 19 (42.2%) of them received allo-HSCT, and 5 (55.6%) ASCT, respectively. For one patient information was missing.
Status at first HSCT
Thirty-three (60%) patients were in CR before the first HSCT, 16 (29.1%) were in PR or very good PR (VGPR). 6 (10.9%) patients showed PD at first HSCT. In our cohort all 7 patients with HSTCL, and 22/38 patients with PTCL-NOS were in CR1/PR1 at HSCT. Conversely, only one of four patients with AITL and one of three patients with ENKTCL were in CR1/PR1 at HSCT. Most of the younger patients (<7 years) achieved CR1/PR1 prior to HSCT (8 out of 9 patients). Patients with stage I/II disease all achieved a CR1/PR1 status, while patients with stage III or IV were in CR1/PR1 in 29% and 68%, respectively. 56.5% of patients presenting with B-symptoms were in CR1/PR1 before HSCT. Table 2 describes status at first HSCT.
HSCT
Forty-six patients underwent allo-HSCT, and 9 patients ASCT (eight patients with PTCL-NOS and one with SPTCL). All patients diagnosed with HSTCL, AITL, ENKTCL or systemic EBV-positive T-cell lymphoma of childhood, and all patients with a known preexisting condition underwent allo-HSCT (Table 3).
Donor and stem cell source
HLA-matched family donors were used in 15 patients (13 identical siblings, 1 syngeneic twin, and 1 other, respectively). Seventeen patients were transplanted from a 10/10 HLA-matched unrelated donor, 5 from a 9/10 unrelated donor, 1 from 8/10 unrelated donor. One patient received haploidentical HSCT, and 2 unrelated single-cord-blood transplantation. In five patients transplanted from unrelated donors there were no records on HLA-typing. Bone marrow (BM), peripheral blood stem cells (PBSC), and cord blood were the stem cell source in 24, 20, and 2 patients for allo-HSCT, respectively. All patients with ASCT received PBSC (Table 3).
Conditioning regimen
The conditioning regimen varied considerably in the studied population. Myelo-ablative-conditioning (MAC) was used in 49 (89.1%) patients (all ASCT and 87% of the allo-HSCT). Only six patients, who were in remission (CR/PR or VGPR) prior to HSCT received non-myeloablative regimen prior to allo-HSCT.
Total body irradiation (TBI) was part of the conditioning regimen in 27 patients receiving allo-HSCT (58.7%). TBI-based conditioning (12 Gy, 10 Gy, and 6 Gy in 23, 1 and 2 patients, respectively (TBI-dose for one patient missing) comprised either cyclophosphamide or etoposide (Table 3). TBI was preferred over chemotherapy-based conditioning in patients not in first remission (CR1/PR1 or VGPR = 1) prior to HSCT (59.1% vs. 40.9%). In this group TBI/etoposide-based conditioning was used more frequently than TBI/cyclophosphamide-based conditioning (10 vs. 3 patients, respectively). 57.6% of the patients in remission received chemotherapy-based conditioning without TBI.
The most common non-TBI conditioning regimen for allo-HSCT was busulfan-based (in 12 (21.8%) patients). Busulfan-free conditioning were mostly fludarabine-based. Most common conditioning prior to ASCT was BEAM (cytarabine, BCNU, etoposide, melphalan), that was used in 4 patients (Table 3).
In-vivo T-cell depletion was performed in 28 (63.6%) of the allografts, graft manipulation ex-vivo was done in 4 (7.4%) cases (Table 3).
Outcome after HSCT
With a median follow-up of 6.9 years (95% CI 5.4–8.1) the 5-year OS and PFS was 58.9% (95% CI 42.7–71.9) and 52.6% (95% CI 36.8–66.1), respectively, for patients who received allo-HSCT. The 5-year cumulative RI for patients with allo-HSCT was 27.6% (95% CI 15.1–41.6), whereas the 5-year NRM was 19.8% (95% CI 9.7–32.6), (Fig. 2).
After ASCT, with median follow-up of 9.9 years (95% CI 4.5–14.1), seven of nine patients remained in remission and were alive at last follow-up. One patient transplanted in CR1 relapsed after ASCT, proceeded to allo-HSCT 80 days after the ASCT, subsequently developed extensive chronic GvHD and died of HSCT-related cause. Another patient also died of HSCT-related cause after transplantation in PD-status. (Table 4).
Table 5 shows the outcome according to remission status prior to the HSCT. There was no major difference in OS between patients transplanted in first remission (CR1/PR1) versus CR/PR > 1. Of the six patients not in remission prior to the HSCT one patient was treated with a tandem-ASCT and died 73 days after the first ASCT of SCT-related cause. Five patients received allo-HSCT, 4 of them relapsed and died of PTCL.
Of the 8 patients with primary- (4) or secondary (4) immunodeficiency, 5 (62.5%) survived, one patient died of infection, two relapsed and died of lymphoma progression (Table 6).
Engraftment
The cumulative incidence of leukocyte engraftment within 30 days after allo-HSCT was 88.6% (95% CI 73.6–95.4). All patients engrafted after ASCT (Table 4). Of the five patients with no or delayed engraftment, four died of SCT-related causes.
Relapses after first HSCT and NRM
Relapse was observed in 11 patients after allo-HSCT, and in one patient after ASCT. Ten of them died of lymphoma. NRM was observed in 9 patients after allo-HSCT, and 2 patients after ASCT. There were 3 early deaths without engraftment, and 4 more before day +100 after allo-HSCT. The main causes of death were infections in 5 patients, alone or in combination with veno-occlusive disease (3 patients), and/or GvHD (2 patients). Two patients died of CNS toxicity.
GvHD
The univariate analysis showed the incidence of acute GvHD grade II-IV within 100 days after allo-HSCT of 41.9% (95% CI 26.9–56.1). The incidence of severe aGvHD (grade III/IV) within 100 days was 16.3% (95% CI 7.1–28.8). The incidence of chronic GvHD was 11.9% (95% CI 4.2–23.8) and the incidence of extensive chronic GvHD was 4.8% (95% CI 0.8–14.6).
Discussion
In contrast to adult patients, few studies investigated the role of HSCT in treatment of PTCL in the pediatric population. The heterogeneity of the diseases as well as better outcome for most of the pediatric PTCL-subtypes after first-line therapy compared to their adult counterparts, render extrapolating results from adult studies difficult.
In pediatric studies EFS/OS varied considerably between the different subtypes. In the up to now largest survey of pediatric patients with PTCL by the EICNHL and I-BFM Study Group [7] comprising 143 patients, 5-year OS and EFS for all patients was 0.56 ± 0.05 and 0.45 ± 0.05, respectively. Relapse occurred in 27%. Twenty-five patients (17.5%) were chemotherapy-refractory. The subgroup analysis revealed following 5-year OS: PTCL-NOS 56%, ENKTCL 59%, SPTCL 78%, HSTCL 13% [7]. The COG-group reported an even better outcome (5-year OS 70%, EFS 60%) from the analysis of 20 pediatric patients with PTCL [9]. In contrast, the largest retrospective study of 1314 adult patients with PTCL excluding ALK + ALCL showed a 5-year OS of approximately 35% [17].
In view of the poor outcome with conventional chemotherapy, high-dose-chemotherapy and ASCT have been proposed for consolidation in adults with chemotherapy-sensitive disease following the results of many retrospective and prospective single-arm studies. Most of the studies report 5-year PFS and OS rates of 41–46%, and 50–70%, respectively for patients who received ASCT in CR1, as compared to 5-year PFS and OS rates of 20–40%, and 26–66% for those not receiving ASCT in CR1 [18,19,20,21,22,23,24,25]. The potential benefit of ASCT applies only to relatively young and fit patients with chemotherapy-sensitive PTCL. However, in many studies patients with ALCL were included, making outcome estimates for patients with non-anaplastic PTCL more difficult.
In our cohort, out of 9 patients with PTCL (8 PTCL-NOS, 1 SPTCL) receiving ASCT, 6 were in CR1 and 2 in CR2. Of those transplanted in CR, 7 were alive at last follow up. Similar results were reported by Kobayashi et al. [26] with 7 pediatric PTCL patients who underwent ASCT, 4 of them in CR1. The estimated 5-year EFS of 50% and OS of 75% was slightly better than the 5-year OS/EFS of 66.7% for patients receiving ASCT after induction failure/relapse [26]. In another series only single pediatric patients received ASCT for PTCL. Those who reached CR before ASCT remained long term disease-free [7, 8]. Notably, the number of CRs had no adverse influence on the outcome. Given the small numbers from previous studies and our current analysis it remains difficult to recommend selection criteria for consolidative ASCT in first line PTCL-therapy in childhood. It might be an option for patients with intermediate risk, whereas patients with less aggressive subtypes of PTCL and chemotherapy-sensitive disease could maintain a durable CR after conventional chemotherapy with the possibility of a rescue-ASCT in CR2. Achievement of CR prior to ASCT seems to be pivotal prognostic factor, also for children. Therefore, in addition to modern imaging techniques like PET-CT, detection of minimal residual disease should be included in assessment of the disease-status prior to ASCT.
In our analysis 16 patients were transplanted in second remission (11 in CR2, 5 in PR/VGPR2), two of them received ASCT, and 14 allo-HSCT. There were 4 deaths (2 disease-related and 2 NRM). Ten (71%) patients treated with allo-HSCT were alive and disease-free. As suggested by many investigators [3, 7, 26, 27] given the data from our study, we would agree that allo-HSCT could be offered to high-risk patients, as soon as they reach CR.
Twenty-seven patients in our study underwent allo-HSCT as consolidation after first-line therapy. Sixteen were in CR1, three in VGPR1, and eight in PR1. Of those, sixteen (59%) were alive and disease free at the time of analysis, 11 patients died (4 disease progression, 7 NRM). In the Japanese cohort 4 patients received allo-HSCT in CR1/PR1, with a reported 5-year OS of 100% [26]. In another study of 13 children with PTCL, 7 received allo-HSCT, 3 of them in CR. Of the seven patients, 3 were alive, and 4 died of NRM [8]. In another analysis allogeneic and autologous HSCT was conducted in 14 and 2 pediatric patients with PTCL-NOS, respectively, of whom 6 were in CR1, 9 in CR2, and one in PR-status. 5 and 5 of the patients transplanted in CR1 and CR2, respectively, survived, the patient transplanted in PR died [7]. The data, although limited by the small number of patients, show a good efficacy of allo-HSCT and demonstrate a graft-versus-lymphoma effect. However, the high NRM as shown also in our study hampers better outcome.
In our analysis most of the patients with allo-HSCT (87%) received MAC, with 2/3 of the conditioning being TBI-based (67,5%). Considering that veno-occlussive disease and infections were the leading causes of NRM, the high therapy burden of MAC might pose a higher risk of toxic complications. GvHD was reported to have contributed to the NRM in two cases, only.
In adults, allo-HSCT has also been used as consolidation treatment in high-risk PTCL. Compared with ASCT, allo-HSCT led to lower relapse rate, however, at cost of higher NRM [28, 29]. A randomized phase-3 study investigated autologous versus allo-HSCT as part of first-line therapy in high-risk PTCL in adults [30]. There was no significant difference in the 3-years OS between the groups. Relapses were mostly seen after ASCT, whereas NRM (31%) occurred only after allo-HSCT with MAC. This study led to the recommendation to reserve allo-HSCT for relapsed/refractory PTCL. NRM rate of 26% after allo-HSCT in CR/PR1 in our analysis was lower than described in adults, but still substantial. Allo-HSCT in CR/PR1 may thus be an option for pediatric patients with high-risk disease. Use of reduced-intensity conditioning regimen in adults showed a reduction of NRM without compromising the EFS rates [31,32,33]. In our study only 6 patients (13%) received non-myeloablative conditioning, all of them in CR1/PR1. 3 were alive at last follow-up, 3 died of NRM.
Reported outcomes for adults with PD or primary refractory PTCL are very poor, with a median OS of 9.1 months [34]. In our study, 6 patients were transplanted without achieving remission prior to HSCT. Five underwent allo-HSCT, four died of lymphoma after HSCT. The one patient with ASCT at PD died of NRM. In the Japanese study of 19 pediatric patients with PTCL (12 PTCL-NOS, 6 ENKTCL, 1 SPTCL) having induction failure or relapse, who underwent HSCT, the 5-year EFS and OS was 50% for PTCL-NOS patients, and EFS of 50% and OS of 66.7% for ENKTCL, respectively [26]. However, the study did not report the disease status prior to HSCT.
Our study has some limitations. Since we analyzed data from the EBMT registry, only patients receiving HSCT were included. This may have led to selection bias, since on the one hand, patients with a low-risk profile were possibly adequately treated without HSCT. On the other hand, patients with a very high-risk profile might have not reached transplantation or chosen palliative treatment. With the retrospective nature of the study there were no uniform criteria for choosing the mode of transplantation. The primary therapy varied considerably as did the conditioning regimen before HSCT, not allowing for conclusions about the optimal treatment strategies.
In conclusion, this study describes the to date largest group of pediatric patients with PTCL undergoing HSCT. It underlines the role of allo-HSCT for patients with an intermediate to high-risk profile who reach at least partial remission. Due to the rarity of this heterogenic lymphoma group in children, implementation of randomized studies is not feasible even on an international platform. Prospective register studies with defined criteria for entering autologous or allogeneic transplantation might help to find optimal treatment strategies for children with PTCL.
Our data suggest a role of allogeneic HSCT in consolidation-treatment of patients with high-risk disease, who reach at least partial remission after primary- or relapse-therapy, whereas autologous HSCT could be an option for intermediate-risk patients with complete remission. Patients with a PD status prior to transplantation did not profit from HSCT. Further biologic studies about the disease mechanisms and novel therapeutic approaches, including cellular therapies are needed for these patients.
Data availability
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
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The authors wish to acknowledge transplant teams at participating institutions for their dedication and involvement in the daily patient care.
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OM and UK designed the study. AD, SC, AA, BB, WW and KK supervised the study. J-HB, KC, J-HD, KD, MGV, KK, LLC, KM, MS, JT, GC and MB collected clinical data. MN, J-EG and AD performed data analysis. OM and UK analyzed data and wrote the initial manuscript. All authors red and approved the final manuscript.
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Moser, O., Ngoya, M., Galimard, JE. et al. Hematopoietic stem cell transplantation for pediatric patients with non-anaplastic peripheral T-cell lymphoma. An EBMT pediatric diseases working party study. Bone Marrow Transplant (2024). https://doi.org/10.1038/s41409-024-02226-1
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Accepted:
Published:
DOI: https://doi.org/10.1038/s41409-024-02226-1