Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Chronic fatigue is highly prevalent in survivors of autologous stem cell transplantation and associated with IL-6, neuroticism, cardiorespiratory fitness, and obesity

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

References

  1. Bower JE. Cancer-related fatigue--mechanisms, risk factors, and treatments. Nat Rev Clin Oncol. 2014;11:597–609.

    Article  CAS  Google Scholar 

  2. Loge JH, Abrahamsen AF, Ekeberg O, Kaasa S. Hodgkin’s disease survivors more fatigued than the general population. J Clin Oncol. 1999;17:253–61.

    Article  CAS  Google Scholar 

  3. Seland M, Holte H, Bjoro T, Schreiner T, Bollerslev J, Loge JH, et al. Chronic fatigue is prevalent and associated with hormonal dysfunction in long-term non-Hodgkin lymphoma survivors treated with radiotherapy to the head and neck region. Leuk Lymphoma. 2015;56:3306–14.

    Article  CAS  Google Scholar 

  4. Hjermstad MJ, Fossa SD, Oldervoll L, Holte H, Jacobsen AB, Loge JH. Fatigue in long-term Hodgkin’s Disease survivors: a follow-up study. J Clin Oncol. 2005;23:6587–95.

    Article  Google Scholar 

  5. Zimmer P, Mierau A, Bloch W, Struder HK, Hulsdunker T, Schenk A, et al. Post-chemotherapy cognitive impairment in patients with B-cell non-Hodgkin lymphoma: a first comprehensive approach to determine cognitive impairments after treatment with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone or rituximab and bendamustine. Leuk Lymphoma. 2015;56:347–52.

    Article  CAS  Google Scholar 

  6. Dimeo F, Schmittel A, Fietz T, Schwartz S, Kohler P, Boning D, et al. Physical performance, depression, immune status and fatigue in patients with hematological malignancies after treatment. Ann Oncol. 2004;15:1237–42.

    Article  CAS  Google Scholar 

  7. Hamre H, Zeller B, Kanellopoulos A, Ruud E, Fossa SD, Loge JH, et al. Serum cytokines and chronic fatigue in adults surviving after childhood leukemia and lymphoma. Brain Behav Immun. 2013;30:80–7.

    Article  CAS  Google Scholar 

  8. Kreissl S, Mueller H, Goergen H, Mayer A, Brillant C, Behringer K, et al. Cancer-related fatigue in patients with and survivors of Hodgkin’s lymphoma: a longitudinal study of the German Hodgkin Study Group. Lancet Oncol. 2016;17:1453–62.

    Article  Google Scholar 

  9. Louati K, Berenbaum F. Fatigue in chronic inflammation - a link to pain pathways. Arthritis Res Ther. 2015;17:254.

    Article  Google Scholar 

  10. Steidl C, Connors JM, Gascoyne RD. Molecular pathogenesis of Hodgkin’s lymphoma: increasing evidence of the importance of the microenvironment. J Clin Oncol. 2011;29:1812–26.

    Article  CAS  Google Scholar 

  11. van Rhee F, Rothman M, Ho KF, Fleming S, Wong RS, Fossa A, et al. Patient-reported outcomes for multicentric castleman’s disease in a randomized, placebo-controlled Study of siltuximab. Patient. 2015;8:207–16.

    Article  Google Scholar 

  12. Ng AK, Li S, Recklitis C, Neuberg D, Chakrabarti S, Silver B, et al. A comparison between long-term survivors of Hodgkin’s disease and their siblings on fatigue level and factors predicting for increased fatigue. Ann Oncol. 2005;16:1949–55.

    Article  CAS  Google Scholar 

  13. Mustian KM, Alfano CM, Heckler C, Kleckner AS, Kleckner IR, Leach CR, et al. Comparison of pharmaceutical, psychological, and exercise treatments for cancer-related fatigue: a meta-analysis. JAMA Oncol. 2017;3:961–8.

    Article  Google Scholar 

  14. Kato K, Sullivan PF, Evengard B, Pedersen NL. Premorbid predictors of chronic fatigue. Arch Gen Psychiatry. 2006;63:1267–72.

    Article  Google Scholar 

  15. Daniels LA, Oerlemans S, Krol AD, Creutzberg CL, van de Poll-Franse LV. Chronic fatigue in Hodgkin lymphoma survivors and associations with anxiety, depression and comorbidity. Br J Cancer. 2014;110:868–74.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Knut B. Smeland.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Electronic supplementary material

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Smeland, K.B., Loge, J.H., Aass, H.C.D. et al. Chronic fatigue is highly prevalent in survivors of autologous stem cell transplantation and associated with IL-6, neuroticism, cardiorespiratory fitness, and obesity. Bone Marrow Transplant 54, 607–610 (2019). https://doi.org/10.1038/s41409-018-0342-y

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41409-018-0342-y

This article is cited by

Search

Quick links