Subjects with sickle cell disease produce small EVs that cause damage to endothelial cells in vitro compared to small EVs from subjects without sickle cell disease.1 The damage elicited in endothelial cells is more severe when the EVs are isolated from subjects with sickle cell disease during an episode of ACS.
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Lapping-Carr, G. et al. Circulating extracellular vesicles from patients with acute chest syndrome disrupt adherens junctions between endothelial cells. Pediatr. Res. https://doi.org/10.1038/s41390-020-0923-5 (2020).
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This study was supported by NIH UL1 TR000430, Comer Hospital RBC Race Funds, Ted Mullin Fund.
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Lapping-Carr, G., Gemel, J., Mao, Y. et al. Insights image for “Circulating extracellular vesicles from patients with acute chest syndrome disrupt adherens junctions between endothelial cells”. Pediatr Res 89, 1036 (2021). https://doi.org/10.1038/s41390-020-01288-3
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DOI: https://doi.org/10.1038/s41390-020-01288-3
