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Bench approaches to study the detrimental cutaneous impact of tropospheric ozone

Journal of Exposure Science & Environmental Epidemiology volume 31, pages 137–148 (2021)Cite this article

Abstract

Being exposed to ground-level ozone (O3), as it is often the case in polluted cities, is known to have a detrimental impact on skin. O3 induces antioxidant depletion and lipid peroxidation in the upper skin layers and this effect has repercussions on deeper cellular layers, triggering a cascade of cellular stress and inflammatory responses. Repetitive exposure to high levels of O3 may lead to chronic damages of the cutaneous tissue, cause premature skin aging and aggravate skin diseases such as contact dermatitis and urticaria. This review paper debates about the most relevant experimental approaches that must be considered to gather deeper insights about the complex biological processes that are activated when the skin is exposed to O3. Having a better understanding of O3 effects on skin barrier properties and stress responses could help the whole dermato-cosmetic industry to design innovative protective solutions and develop specific cosmetic regime to protect the skin of every citizen, especially those living in areas where exposure to high levels of O3 is of concern to human health.

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Fig. 1: Example of an O3 exposure experimental set-up.
Fig. 2: Skin tissue models used to assess the effects of O3 on skin.

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Funding

This work was supported by the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement [grant number 765602]. BP and BRR acknowledge the support of the Adolphe Merkle Foundation.

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Authors and Affiliations

  1. Dow Silicones Belgium SRL, Seneffe, Belgium

    Benedetta Petracca & Marc Eeman

  2. Adolphe Merkle Institute, University of Fribourg, Fribourg, Switzerland

    Benedetta Petracca & Barbara Rothen-Rutishauser

  3. Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy

    Giuseppe Valacchi

  4. Department of Animal Sciences, Kannapolis Research Campus, North Carolina State University, Raleigh, NC, USA

    Giuseppe Valacchi

  5. Department of Food and Nutrition, Kyung Hee University, Seoul, Korea

    Giuseppe Valacchi

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  1. Benedetta Petracca
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Correspondence to Marc Eeman.

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Petracca, B., Rothen-Rutishauser, B., Valacchi, G. et al. Bench approaches to study the detrimental cutaneous impact of tropospheric ozone. J Expo Sci Environ Epidemiol 31, 137–148 (2021). https://doi.org/10.1038/s41370-020-00275-4

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