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Metalloproteinase super–families and drug design

The common topology of the matrix metalloproteinase family, and details of the structures of individual members, will intensify efforts to develop drugs for diseases such as arthritis and cancer.

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References

  1. Borkakoti et al., Nature struct. Biol. 1, 106–110 (1994).

    Article  CAS  Google Scholar 

  2. Gooley et al., Nature struct. Biol. 1, 111–118 (1994).

    Article  CAS  Google Scholar 

  3. Stams, T., Spurlino, L., Wahl, R.C., Ho, T.F., Qoronfleth, M.W., Banks, T.M. & Rubin, B. Nature struct. Biol. 1, 119–123 (1994).

    Article  CAS  Google Scholar 

  4. Bode, W., Reinemer, P., Huber, R., Kleine, T., Schneierer, S. and Tschesche EMBO J. (in the press).

  5. Lovejoy, B. et al., Science (in the press).

  6. Docherty, A.J.P. et al., Trends Biology 10, 200–207 (1992).

    CAS  Google Scholar 

  7. Basset, P. et al., Nature 348, 699–704 (1990).

    Article  CAS  Google Scholar 

  8. Bode, W. et al., Nature 358, 164–167 (1992).

    Article  CAS  Google Scholar 

  9. Gomis-Ruth, F.X., Kress, L.F. and Bode, W. EMBO J. 12, 4151–4157 (1993).

    Article  CAS  Google Scholar 

  10. Baumann, U., Wu, S., Flaherty, K.M. & McKay, D.B. EMBO J. In Press, (1994).

    Google Scholar 

  11. Bode, W., Gomis-Ruth, F.X. & Stocker, W. FEBS Lett. 331, 134–140 (1993).

    Article  CAS  Google Scholar 

  12. Johnson, M.J., Overington, J. & Blundell, T.L. J. molec. Biol. 231, 735–752 (1993).

    Article  CAS  Google Scholar 

  13. Grams, F. et al., FEBS Lett. 335, 76–80 (1993).

    Article  CAS  Google Scholar 

  14. Matthews, B.W. et al., Nature new Biol. 238, 37–41 (1972)10.

    Article  CAS  Google Scholar 

  15. Pauptit, R.A. et al. J. molec. Biol. 199, 525–537 (1988).

    Article  CAS  Google Scholar 

  16. Thayer, M.M., Flaherty, K.M. & Mackay, D.B. J. biol. Chem. 266, 2864–2871 (1991).

    CAS  PubMed  Google Scholar 

  17. Schechter, I. and Berger, A. Biochem. Biophys. Res. Commun. 27, 157–162 (1967).

    Article  CAS  Google Scholar 

  18. Johnson, W.H., Roberts, N.A. & Borkakoti, N.J. Enzyme Inhibition 2, 1–22 (1987).

    Article  CAS  Google Scholar 

  19. Weaver, L.H., Kester, W.R. and Matthews, B.W. J. molec. Biol. 114, 119–132 (1977).

    Article  CAS  Google Scholar 

  20. Blundell, T.L. and Johnson, M.J. Prot. Sci. 2, 877–883 (1993).

    Article  CAS  Google Scholar 

  21. Spurlino et al. Proteins (in the press).

Download references

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Blundell, T. Metalloproteinase super–families and drug design. Nat Struct Mol Biol 1, 73–75 (1994). https://doi.org/10.1038/nsb0294-73

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