Young adults with an acute rupture of the anterior cruciate ligament of the knee are faced with the decision of whether or not to undergo early reconstructive surgery. However, a lack of high-quality evidence means questions remain about whether this surgical strategy protects against the development of osteoarthritis in the future.
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Safety, tolerability, clinical, and joint structural outcomes of a single intra-articular injection of allogeneic mesenchymal precursor cells in patients following anterior cruciate ligament reconstruction: a controlled double-blind randomised trial
Arthritis Research & Therapy Open Access 02 August 2017
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References
Brophy, R. H., Gray, B. L., Nunley, R. M., Barrack, R. L. & Clohisy, J. C. Total knee arthroplasty after previous knee surgery: expected interval and the effect on patient age. J. Bone Joint Surg. Am. 96, 801–805 (2014).
Lohmander, L. S., Englund, M., Dahl, L. L. & Roos, E. M. The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis. Am. J. Sports Med. 35, 1756–1769 (2007).
Cox, C. L. et al. Are articular cartilage lesions and meniscus tears predictive of IKDC, KOOS, and Marx activity level outcomes after anterior cruciate ligament reconstruction? A 6-year multicenter cohort study. Am. J. Sports Med. 42, 1058–1067 (2014).
Frobell, R. B., Roos, E. M., Roos, H. P., Ranstam, J. & Lohmander, L. S. A randomized trial of treatment for acute anterior cruciate ligament tear. N. Engl. J. Med. 363, 331–342 (2010).
Frobell, R. B. et al. Treatment for acute anterior cruciate ligament tear: five year outcome of randomised trial. BMJ 346, f232 (2013).
Potter, H. G. et al. Cartilage injury after acute, isolated anterior cruciate ligament tear: immediate and longitudinal effect with clinical/MRI follow-up. Am. J. Sports Med. 40, 276–285 (2012).
Anderson, D. D. et al. Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention. J. Orthop. Res. 29, 802–809 (2011).
Wen, C.-Y., Qin, L., Lee, K.-M., Wong, M. W.-N. & Chan, K.-M. Influence of bone adaptation on tendon-to-bone healing in bone tunnel after anterior cruciate ligament reconstruction in a rabbit model. J. Orthop. Res. 27, 1447–1456 (2009).
Hosseini, A., van de Velde, S., Gill, T. J. & Li, G. Tibiofemoral cartilage contact biomechanics in patients after reconstruction of a ruptured anterior cruciate ligament. J. Orthop. Res. 30, 1781–1788 (2012).
Nia, H. T. et al. High-bandwidth AFM-based rheology reveals that cartilage is most sensitive to high loading rates at early stages of impairment. Biophys. J. 104, 1529–1537 (2013).
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Wen, C., Lohmander, L. Does post-injury ACL reconstruction prevent future OA?. Nat Rev Rheumatol 10, 577–578 (2014). https://doi.org/10.1038/nrrheum.2014.120
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DOI: https://doi.org/10.1038/nrrheum.2014.120
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