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Transplantation

mTOR inhibition in kidney transplant recipients

Nature Reviews Nephrology volume 7, pages 553–555 (2011)Cite this article

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The ASCERTAIN study has confirmed previous findings that conversion from calcineurin inhibitors to mammalian target of rapamycin (mTOR) inhibitors does not seem to improve glomerular filtration rate in renal transplant recipients, although it does seem beneficial in patients with better renal function at baseline. Questions remain regarding the role of mTOR inhibitors in kidney transplantation.

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Author information

Authors and Affiliations

  1. Department of Pharmacy, University Medical Center, 1501 North Campbell Avenue, Tucson, 85724, AZ, USA

    Sarah E. Yost

  2. Department of Medicine, Nephrology Division, University of Arizona College of Medicine, 1501 North Campbell Avenue, Tucson, 85724, AZ, USA

    Rochelle Byrne & Bruce Kaplan

Authors
  1. Sarah E. Yost
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  2. Rochelle Byrne
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  3. Bruce Kaplan
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Corresponding author

Correspondence to Bruce Kaplan.

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The authors declare no competing financial interests.

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Yost, S., Byrne, R. & Kaplan, B. mTOR inhibition in kidney transplant recipients. Nat Rev Nephrol 7, 553–555 (2011). https://doi.org/10.1038/nrneph.2011.125

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