Nature Reviews Molecular Cell Biology 16, 577 (2015)
It has come to our attention that findings similar to those summarized in this Research Highlight were reported earlier in Development Cell by Chavez et al., providing insight into the role of phosphoinositides in ciliary trafficking and in the regulation of Hedgehog signalling. In this study, inactivation of inositol polyphosphate 5-phosphatase E resulted in the accumulation of phosphatidylinositol-(4,5)-bisphosphate and of negative regulators of Hedgehog signalling in the cilia of neural stem cells, leading to fewer hippocampal neurons in adult mice.
References
Chavez, M. et al. Modulation of ciliary phosphoinositide content regulates trafficking and Sonic Hedgehog signaling output. Dev. Cell 34, 338–350 (2015)
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Wrighton, K. Ciliary phosphoinositides regulate Hedgehog signalling. Nat Rev Mol Cell Biol 16, 641 (2015). https://doi.org/10.1038/nrm4075
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DOI: https://doi.org/10.1038/nrm4075
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