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Preventing 5 million child deaths from diarrhea in the next 5 years

Despite major advances in understanding its prevention and treatment, diarrhea remains a leading cause of global child deaths and a potentially important cause of lifelong morbidity. A new study asks the question: how many lives would be saved by universal scaling up of best practices for diarrhea prevention and control?

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Figure 1: Percentage of child deaths under 5 years of age averted in 2015 via the universal scale-up of a program for the prevention and treatment of diarrhea in 68 high priority countries.

References

  1. Virchow, R. C. Report on the typhus epidemic in Upper Silesia. 1848. Am. J. Public Health. 96, 2102–2105 (2006).

    Article  PubMed  PubMed Central  Google Scholar 

  2. UNICEF. Progress for Children: Achieving the MDGs with Equity (No. 9) [online], http://www.unicef.org/publications/index_55740.html (2010).

  3. Black, R. E. et al. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet 375, 1969–1987 (2010).

    Article  PubMed  Google Scholar 

  4. Walker, C. L. F. et al. Scaling up diarrhea prevention and treatment interventions: a lives saved tool analysis. PLoS Med. 8, e1000428 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Serazin, A. C., Shackelton, L. A., Wilson, C. & Bhan, M. K. Improving the performance of enteric vaccines in the developing world. Nat. Immunol. 11, 769–773 (2010).

    Article  CAS  PubMed  Google Scholar 

  6. Moore, S. R. et al. Early childhood diarrhoea and helminthiases associated with long-term linear growth faltering. Int. J. Epidemiol. 30, 1457–1464 (2001).

    Article  CAS  PubMed  Google Scholar 

  7. Guerrant, D. I. et al. Association of early childhood diarrhea and cryptosporidiosis with impaired physical fitness and cognitive function four–seven years later in a poor urban community in northeast Brazil. Am. J. Trop. Med. Hyg. 61, 707–713 (1999).

    Article  CAS  PubMed  Google Scholar 

  8. Pinkerton, R. C. et al. Distinct effects of early childhood diarrhea and stunting on cognitive performance in later childhood: a prospective cohort study in northeastern Brazilian children. Presented at the 3rd World Congress of Pediatric Gastroenterology, Hepatology, & Nutrition.

  9. Eppig, C., Fincher, C. L. & Thornhill, R. Parasite prevalence and the worldwide distribution of cognitive ability. Proc. Biol. Sci. 277, 3801–3808 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Guerrant, R. L. et al. Malnutrition as an enteric infectious disease with long-term effects on child development. Nutr. Rev. 66, 487–505 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Guerrant, R. L. et al. Updating the DALYs for diarrhoeal disease. Trends Parasitol. 18, 191–193 (2002).

    Article  PubMed  Google Scholar 

Download references

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Correspondence to Sean R. Moore.

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Moore, S., Lima, A. & Guerrant, R. Preventing 5 million child deaths from diarrhea in the next 5 years. Nat Rev Gastroenterol Hepatol 8, 363–364 (2011). https://doi.org/10.1038/nrgastro.2011.103

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