Despite major advances in understanding its prevention and treatment, diarrhea remains a leading cause of global child deaths and a potentially important cause of lifelong morbidity. A new study asks the question: how many lives would be saved by universal scaling up of best practices for diarrhea prevention and control?
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Calcimimetic acts on enteric neuronal CaSR to reverse cholera toxin-induced intestinal electrolyte secretion
Scientific Reports Open Access 18 May 2018
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References
Virchow, R. C. Report on the typhus epidemic in Upper Silesia. 1848. Am. J. Public Health. 96, 2102–2105 (2006).
UNICEF. Progress for Children: Achieving the MDGs with Equity (No. 9) [online], http://www.unicef.org/publications/index_55740.html (2010).
Black, R. E. et al. Global, regional, and national causes of child mortality in 2008: a systematic analysis. Lancet 375, 1969–1987 (2010).
Walker, C. L. F. et al. Scaling up diarrhea prevention and treatment interventions: a lives saved tool analysis. PLoS Med. 8, e1000428 (2011).
Serazin, A. C., Shackelton, L. A., Wilson, C. & Bhan, M. K. Improving the performance of enteric vaccines in the developing world. Nat. Immunol. 11, 769–773 (2010).
Moore, S. R. et al. Early childhood diarrhoea and helminthiases associated with long-term linear growth faltering. Int. J. Epidemiol. 30, 1457–1464 (2001).
Guerrant, D. I. et al. Association of early childhood diarrhea and cryptosporidiosis with impaired physical fitness and cognitive function four–seven years later in a poor urban community in northeast Brazil. Am. J. Trop. Med. Hyg. 61, 707–713 (1999).
Pinkerton, R. C. et al. Distinct effects of early childhood diarrhea and stunting on cognitive performance in later childhood: a prospective cohort study in northeastern Brazilian children. Presented at the 3rd World Congress of Pediatric Gastroenterology, Hepatology, & Nutrition.
Eppig, C., Fincher, C. L. & Thornhill, R. Parasite prevalence and the worldwide distribution of cognitive ability. Proc. Biol. Sci. 277, 3801–3808 (2010).
Guerrant, R. L. et al. Malnutrition as an enteric infectious disease with long-term effects on child development. Nutr. Rev. 66, 487–505 (2008).
Guerrant, R. L. et al. Updating the DALYs for diarrhoeal disease. Trends Parasitol. 18, 191–193 (2002).
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Moore, S., Lima, A. & Guerrant, R. Preventing 5 million child deaths from diarrhea in the next 5 years. Nat Rev Gastroenterol Hepatol 8, 363–364 (2011). https://doi.org/10.1038/nrgastro.2011.103
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DOI: https://doi.org/10.1038/nrgastro.2011.103
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