Safety is an important issue for all drugs, but even more so for treatments of non-life-threatening conditions, such as growth hormone (GH) therapy to increase adult stature. Given the almost ubiquitous expression of receptors for GH and its effector, insulin-like growth factor I, GH treatment has the potential to influence several parameters of organism biology.
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References
Carel, J. C. et al. Long-term mortality after recombinant growth hormone treatment for isolated growth hormone deficiency or childhood short stature: preliminary report of the French SAGhE Study. J. Clin. Endocrinol. Metab. http://dx.doi.org/10.1210/jc.2011-1995.
Ajuk, J. & Sheppard, M. C. Mortality following pituitary radiotherapy. Pituitary 6, 35–39 (2009).
Sävendahl, L. et al. Long-term mortality and causes of death in isolated, ghd, iss, and sga patients treated with recombinant growth hormone during childhood in Belgium, The Netherlands, and Sweden: preliminary report of 3 countries participating in the EU SAGhE Study. J. Clin. Endocrinol. Metab. http://dx.doi.org/10.1210/jc.2011-2882.
Dekkers, O. M., von Elm, E., Algra, A., Romijn, J. A. & Vandenbroucke, J. P. How to assess the external validity of therapeutic trials: a conceptual approach. Int. J. Epidemiol. 39, 89–94 (2010).
van Pareren, Y. K. et al. Final height in girls with turner syndrome after long-term growth hormone treatment in three dosages and low dose estrogens. J. Clin. Endocrinol. Metab. 88, 1119–1125 (2003).
Loche, S. et al. Results of early reevaluation of growth hormone secretion in short children with apparent growth hormone deficiency. J. Pediatr. 140, 445–449 (2002).
Aguiar-Oliveira, M. H. et al. Longevity in untreated congenital growth hormone deficiency due to a homozygous mutation in the GHRH receptor gene. J. Clin. Endocrinol. Metab. 95, 714–721 (2010).
Guevara-Aguirre, J. et al. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci. Transl. Med. 3, 70ra13 (2011).
Gallagher, E. J. & Leroith, D. Minireview: IGF, insulin, and cancer. Endocrinology 152, 2546–2551 (2011).
Albertsson-Wikland, K. et al. Dose-dependent effect of growth hormone on final height in children with short stature without growth hormone deficiency. J. Clin. Endocrinol. Metab. 93, 4342–4350 (2008).
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The author declares an association with the following company: Novo Nordisk (consultant).
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Salvatori, R. Growth hormone therapy—is it worth the risk?. Nat Rev Endocrinol 8, 259–260 (2012). https://doi.org/10.1038/nrendo.2012.23
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DOI: https://doi.org/10.1038/nrendo.2012.23