New studies have affirmed the complexity of genetic changes in solid tumours, but also revealed commonalities in the associated pathways, suggesting that a pathway-oriented perspective could aid cancer drug discovery and therapy.
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References
Jones, S. et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321, 1801–1806 (2008).
Williams Parsons, D. An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807–1812 (2008).
The Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 4 Sep 2008 (doi: 10.1038/nature07385).
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Jones, D. Pathways to cancer therapy. Nat Rev Drug Discov 7, 875–876 (2008). https://doi.org/10.1038/nrd2748
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DOI: https://doi.org/10.1038/nrd2748
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