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Coronary artery disease

Can aminothiols be distinguished from reactive oxygen species?

Nature Reviews Cardiology volume 13, pages 128–130 (2016)Cite this article

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Glutathione is considered the major natural antioxidant, protecting cells from oxidative stress. Patel and colleagues used plasma levels of the aminothiols cystine and glutathione to quantify oxidative stress in patients with coronary artery disease, and show that the cystine/glutathione ratio is associated with increased mortality. Is this a new approach for clinical risk stratification?

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Figure 1: Interplay between aminothiol species and reactive oxygen species.

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Authors and Affiliations

  1. Luc Rochette and Catherine Vergely are at the Laboratoire de Physiopathologie et Pharmacologies Cardio-Métaboliques (LPPCM) INSERM UMR866, Facultés des Sciences de Santé, Université de Bourgogne, 7 Boulevard Jeanne d'Arc, 21033 Dijon Cedex, France.,

    Luc Rochette & Catherine Vergely

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  1. Luc Rochette
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  2. Catherine Vergely
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Correspondence to Luc Rochette.

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The authors declare no competing financial interests.

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Rochette, L., Vergely, C. Can aminothiols be distinguished from reactive oxygen species?. Nat Rev Cardiol 13, 128–130 (2016). https://doi.org/10.1038/nrcardio.2016.20

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